CAJ | 학술논문

背景:应用皮肤软组织扩张器植入正常的皮肤软组织下,通过增加扩张器内的容量,对皮肤表面软组织产生压力,使其扩张产生“额外”的皮肤软组织,已成为皮肤组织工程研究领域的基本技术手段.目的:通过狗皮肤扩张移植模型了解扩张皮肤在移植后的近期和远期的变化规律.方法:随机抽取12只成年狗,在其背部置入150 mL 的4个扩张器,其中2个不扩张进行对照.测试扩张不同时间后皮肤应力-应变、应力松弛、极限抗拉强度的结果,并对比分析测定结果.结果与结论:经过扩张,皮肤的黏弹性、强度发生明显降低,黏弹性可在移植后6个月恢复,强度恢复较慢.在行皮肤移植后,生物力学的变化仅为暂时现象,可以恢复至正常,临床应给予关注.
배경:응용피부연조직확장기식입정상적피부연조직하,통과증가확장기내적용량,대피부표면연조직산생압력,사기확장산생“액외”적피부연조직,이성위피부조직공정연구영역적기본기술수단.목적:통과구피부확장이식모형료해확장피부재이식후적근기화원기적변화규률.방법:수궤추취12지성년구,재기배부치입150 mL 적4개확장기,기중2개불확장진행대조.측시확장불동시간후피부응력-응변、응력송이、겁한항랍강도적결과,병대비분석측정결과.결과여결론:경과확장,피부적점탄성、강도발생명현강저,점탄성가재이식후6개월회복,강도회복교만.재행피부이식후,생물역학적변화부위잠시현상,가이회복지정상,림상응급여관주.
@@@@BACKGROUND: A skin soft tissue dilator is implanted into the normal skin, generating pressure to expand the skin soft tissue to produce “extra” skin soft tissues by increasing the capacity within the dilator. This technique has become a basic method in skin tissue engineering. OBJECTIVE: To establish a dog model of expanded skin grafting and to observe the short-term and long-term regular patterns fol owing skin expansion and grafting. METHODS: Twelve adult dogs were randomly selected. Four dilators of 150 mL, two of which did not work as controls, were implanted into the back of dogs. Skin stress-strain, stress relaxation, and ultimate tensile strength were detected and compared at different periods after skin expansion. RESULTS AND CONCLUSION: The skin viscoelasticity and intensity reduced significantly after skin expansion. The viscoelasticity could restore the normal value within 6 months, and the intensity, however, had a slower recovery. As biomechanical changes occur provisional y and can be restored after skin grafting, a more attention should be paid in clinic.