CAJ | 학술논문

组织构建%组织构建学术探讨%组织工程%神经导管支架%力学性能%生物相容性%导电性%生物活性%神经营养因子%支持细胞%种子蛋白%周围神经损伤%国家自然科学基金%组织构建图片文章組織構建%組織構建學術探討%組織工程%神經導管支架%力學性能%生物相容性%導電性%生物活性%神經營養因子%支持細胞%種子蛋白%週圍神經損傷%國傢自然科學基金%組織構建圖片文章
조직구건%조직구건학술탐토%조직공정%신경도관지가%역학성능%생물상용성%도전성%생물활성%신경영양인자%지지세포%충자단백%주위신경손상%국가자연과학기금%조직구건도편문장

背景:组织工程构建技术是近年来周围神经损伤修复的重要方法之一,在周围神经治疗领域有着良好的前景.目的:总结近年来利用组织工程学构建技术对周围神经损伤修复的研究进展.方法:应用计算机检索万方数据库、CNKI 和 PubMed 数据库中1995年1月至2011年12月关于组织工程构建技术的文章,在标题和摘要中以“组织工程,神经导管支架,生物活性,周围神经损伤”或“Tissue engineering,Nerve scaffold,Bioactivity,Peripheral nerve defect”为检索词进行检索,初检得到156篇文献,最终纳入56篇文献进行综述.结果与结论:周围神经损伤组织工程修复的两个要素是神经支架材料的选择和生物功能化.构建神经的支架材料包括可降解和非可降解两大类,通常需要具有三维多孔结构和相应的孔隙率及比表面积,其力学性能、表面活性、生物相容性和导电性等直接影响神经损伤修复的效果;生物功能化的主要生物活性因子包括支持细胞,种子蛋白和神经营养因子,将这些生物活性因子接种在神经导管支架材料上,促进受损神经的修复与功能替代.组织工程技术应用于周围神经损伤修复与再生的研究重点在于导管、细胞与生长因子的综合应用.组织工程技术与生物技术的联合应用将成为周围神经损伤修复的研究热点.
배경:조직공정구건기술시근년래주위신경손상수복적중요방법지일,재주위신경치료영역유착량호적전경.목적:총결근년래이용조직공정학구건기술대주위신경손상수복적연구진전.방법:응용계산궤검색만방수거고、CNKI 화 PubMed 수거고중1995년1월지2011년12월관우조직공정구건기술적문장,재표제화적요중이“조직공정,신경도관지가,생물활성,주위신경손상”혹“Tissue engineering,Nerve scaffold,Bioactivity,Peripheral nerve defect”위검색사진행검색,초검득도156편문헌,최종납입56편문헌진행종술.결과여결론:주위신경손상조직공정수복적량개요소시신경지가재료적선택화생물공능화.구건신경적지가재료포괄가강해화비가강해량대류,통상수요구유삼유다공결구화상응적공극솔급비표면적,기역학성능、표면활성、생물상용성화도전성등직접영향신경손상수복적효과;생물공능화적주요생물활성인자포괄지지세포,충자단백화신경영양인자,장저사생물활성인자접충재신경도관지가재료상,촉진수손신경적수복여공능체대.조직공정기술응용우주위신경손상수복여재생적연구중점재우도관、세포여생장인자적종합응용.조직공정기술여생물기술적연합응용장성위주위신경손상수복적연구열점.
@@@@BACKGROUND: In recent years, tissue engineering construction technology is one of the important methods for peripheral nerve repair, which has a good prospect in the field for peripheral nerve therapy. OBJECTIVE: To summarize the research of repairing peripheral nerve defect using tissue engineering construction technology in the past few years. METHODS: The articles related to tissue engineering construction technology in Wanfang database, CNKI database and PubMed database published from January 1995 to December 2011 were retrieved with the key words of “tissue engineering, nerve scaffold, bioactivity, peripheral nerve defect” in Chinese and English, respectively. Final y, 55 of 156 articles were included in result analysis. RESULTS AND CONCLUSION: The two factors of tissue engineering to the repair of peripheral nerve injury are the choice of nerve conduit materials and biofunctionalization. The materials to construct the nerve conduits include biodegradable and nonbiodegradable materials, usual y with three-dimensional structure, corresponding porosity and specific surface area. Their mechanical properties, surface activity, biocompatibility and conductivity directly affect the results of nerve damage repair. The main bioactive factors of biofunctionalization include the supporting cells, seed storage proteins and neurotrophic factors, and vaccinating these bioactive factors onto the nerve conduits can promote the nerve repair capacity and functional substitute. The main purpose to study the tissue engineering techniques used in the research of peripheral nerve injury repairing and regeneration lies in the comprehensive application of the catheter, cells and growth factors. The combination of tissue engineering technology and biotechnology wil be becoming a hot topic of repairing peripheral nerve injury.