CAJ | 학술논문

组织构建%组织构建临床实践%谷草转氨酶%谷丙转氨酶%谷草转氨酶/谷丙转氨酶%冠状动脉病变%Gensini 积分%年龄%性别%低密度脂蛋白胆固醇%高密度脂蛋白胆固醇%血糖%国家自然科学基金組織構建%組織構建臨床實踐%穀草轉氨酶%穀丙轉氨酶%穀草轉氨酶/穀丙轉氨酶%冠狀動脈病變%Gensini 積分%年齡%性彆%低密度脂蛋白膽固醇%高密度脂蛋白膽固醇%血糖%國傢自然科學基金
조직구건%조직구건림상실천%곡초전안매%곡병전안매%곡초전안매/곡병전안매%관상동맥병변%Gensini 적분%년령%성별%저밀도지단백담고순%고밀도지단백담고순%혈당%국가자연과학기금

背景:国际上相关研究提示外周血中谷草转氨酶、谷丙转氨酶水平可作为心血管危险因素的新生物学标志物.目的:观察分析多民族间谷草转氨酶/谷丙转氨酶比值与冠脉粥样硬化严重程度的关系.方法:回顾性分析730例行冠状动脉造影患者的资料,其中汉族455例;回族51例;维吾尔族126例;哈萨克族63例;其他民族35例.按民族的不同进行分组,以 Gensini 积分对血管狭窄程度进行分析.比较各组谷草转氨酶与谷丙转氨酶比值与冠脉粥样硬化严重程度的关系.结果与结论:谷草转氨酶/谷丙转氨酶在不同民族间(P=0.415)分布差异无显著性意义.患者年龄、性别、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、血糖、谷丙转氨酶、谷草转氨酶及谷草转氨酶/谷丙转氨酶在不同 Gensini 积分组间的分布差异有显著性意义.Spearman 相关分析结果显示年龄、低密度脂蛋白胆固醇、谷丙转氨酶、谷草转氨酶、谷草转氨酶/谷丙转氨酶、血糖与 Gensini 积分呈显著正相关,高密度脂蛋白胆固醇与 Gensini 积分呈显著负相关.提示谷草转氨酶/谷丙转氨酶比值与在多民族人群中与冠状动脉粥样硬化严重程度呈显著正相关.
배경:국제상상관연구제시외주혈중곡초전안매、곡병전안매수평가작위심혈관위험인소적신생물학표지물.목적:관찰분석다민족간곡초전안매/곡병전안매비치여관맥죽양경화엄중정도적관계.방법:회고성분석730례행관상동맥조영환자적자료,기중한족455례;회족51례;유오이족126례;합살극족63례;기타민족35례.안민족적불동진행분조,이 Gensini 적분대혈관협착정도진행분석.비교각조곡초전안매여곡병전안매비치여관맥죽양경화엄중정도적관계.결과여결론:곡초전안매/곡병전안매재불동민족간(P=0.415)분포차이무현저성의의.환자년령、성별、고밀도지단백담고순、저밀도지단백담고순、혈당、곡병전안매、곡초전안매급곡초전안매/곡병전안매재불동 Gensini 적분조간적분포차이유현저성의의.Spearman 상관분석결과현시년령、저밀도지단백담고순、곡병전안매、곡초전안매、곡초전안매/곡병전안매、혈당여 Gensini 적분정현저정상관,고밀도지단백담고순여 Gensini 적분정현저부상관.제시곡초전안매/곡병전안매비치여재다민족인군중여관상동맥죽양경화엄중정도정현저정상관.
@@@@BACKGROUND: There is a growing clinical interest in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) as novel biomarkers of cardiovascular risk factors. OBJECTIVE: To investigate the relationship between the ratio of AST/ALT and severity of coronary atherosclerosis in a multi-ethnic population. METHODS: Total y 730 adult patients, including 455 subjects of Han nationality, 126 of Uygur nationality, 63 of Kazakh nationality, 51 of Hui nationality, and 35 of other nationalities, who underwent coronary angiography for suspected or known coronary atherosclerosis were enrol ed in the present study. And, the severity of coronary atherosclerosis was defined by the Gensini score. Relationship of the ratio of AST/ALT with the severity of coronary atherosclerosis was investigated. RESULTS AND CONCLUSION: A significant difference in the level of AST/ALT was not found among the various ethnic groups. Age, gender, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, fasting blood glucose, ALT, AST, and AST/ALT differed significantly among the subjects in the Gensini score quartile. Spearman correlation analyses indicated that the Gensini score was significantly positively associated with age, low-density lipoprotein cholesterol, fasting blood glucose, AST, ALT and AST/ALT, but negatively associated with high-density lipoprotein cholesterol. The AST/ALT was significantly associated with the severity of coronary atherosclerosis in the multi-ethnic population.