CAJ | 학술논문

背景:纳米羟基磷灰石与聚氨酯复合材料在体外实验中具有良好的相容性.目的:验证纳米羟基磷灰石膜聚氨酯复合材料在大鼠体内的组织相容性.方法:将18只 SD 大鼠随机分为复合材料组、聚氨酯组和对照组,复合材料组和聚氨酯组分别将纳米羟基磷灰石膜聚氨酯复合材料、聚氨酯植入大鼠背部肌肉内,对照组仅作切开缝合,未植入任何材料.结果与结论:①大体观察:术后12周,各组切口与周围皮肤几乎无界限,聚氨酯组及复合材料组囊壁与材料融合较好,对照组皮肤已恢复正常.②组织学观察:术后4,8,12周,聚氨酯组及复合材料组切口周围组织中淋巴细胞数、中性粒细胞数及毛细血管量均高于对照组(P <0.05),复合材料组切口周围组织中淋巴细胞数、中性粒细胞数及毛细血管量均少于聚氨酯组(P <0.05).证实纳米羟基磷灰石膜聚氨酯复合材料具有较好的组织相容性.
배경:납미간기린회석여취안지복합재료재체외실험중구유량호적상용성.목적:험증납미간기린회석막취안지복합재료재대서체내적조직상용성.방법:장18지 SD 대서수궤분위복합재료조、취안지조화대조조,복합재료조화취안지조분별장납미간기린회석막취안지복합재료、취안지식입대서배부기육내,대조조부작절개봉합,미식입임하재료.결과여결론:①대체관찰:술후12주,각조절구여주위피부궤호무계한,취안지조급복합재료조낭벽여재료융합교호,대조조피부이회복정상.②조직학관찰:술후4,8,12주,취안지조급복합재료조절구주위조직중림파세포수、중성립세포수급모세혈관량균고우대조조(P <0.05),복합재료조절구주위조직중림파세포수、중성립세포수급모세혈관량균소우취안지조(P <0.05).증실납미간기린회석막취안지복합재료구유교호적조직상용성.
@@@@BACKGROUND: Nano-hydroxyapatite/polyurethane has been verified to have an excel ent biocompatibility in vitro. OBJECTIVE: To explore the biocompatibility between nano-hydroxyapatite/polyurethane composite and mouse tissues. METHODS: Eighteen Sprague-Dawley rats were randomly divided into nano-hydroxyapatite/polyurethane group, polyurethane group and control group. Polyurethane and nano-hydroxyapatite/polyurethane were implanted into the back of rats, respectively, in the polyurethane and nano-hydroxyapatite/polyurethane groups. Nothing was implanted in the control group. RESULTS AND CONCLUSION: (1) Body observation: Incision and surrounding skin almost had no boundaries in al the groups 12 weeks after operation. The capsule wal of polyurethane and nano-hydroxyapatite/ polyurethane groups was confluent wel with the implant materials, and the skin of the control group recovered. (2) Histology observation: The number of lymphocytes, neutrophils and capil ary vessels around the incisions was higher in the polyurethane and nano-hydroxyapatite/polyurethane groups than the control group (P < 0.05). In addition, nano-hydroxyapatite/polyurethane group has fewer lymphocytes, neutrophils and capil ary vessels than the polyurethane groups (P < 0.05). It is verified that nano-hydroxyapatite/polyurethane composite has a better histocompatibility.