CAJ | 학술논문

背景:快速成型是基于材料堆积法,结合计算机、数控、激光和材料技术于一体的高新制造技术.目的:综述快速成型技术在组织工程支架制备中的应用.方法:由第一作者检索万方数据库、中国知网数据库和 Elsevier Science Direct Online 有关支架材料的生物力学性能、支架材料发展前景及快速成型技术在支架材料制备领域中应用研究等方面的文献.结果与结论:快速成型技术应用于组织工程支架的制备已经越来越成熟,快速成型技术不但克服了传统制造方法中存在的支架复杂外形制造困难和内部微结构无法控制的缺陷,而且还可以通过有限元分析预先对支架的结构进行优化,以实现改善支架机械强度等某些特殊的要求.但是,由于组织器官的特殊性和排外性及细胞的黏附条件,不但要从结构上改善支架,而且需要快速成型技术与具有组织相容性及可降解的材料相结合,使支架植入生物体后,细胞能更好地增殖和分化,促进组织再生,修复缺损组织.
배경:쾌속성형시기우재료퇴적법,결합계산궤、수공、격광화재료기술우일체적고신제조기술.목적:종술쾌속성형기술재조직공정지가제비중적응용.방법:유제일작자검색만방수거고、중국지망수거고화 Elsevier Science Direct Online 유관지가재료적생물역학성능、지가재료발전전경급쾌속성형기술재지가재료제비영역중응용연구등방면적문헌.결과여결론:쾌속성형기술응용우조직공정지가적제비이경월래월성숙,쾌속성형기술불단극복료전통제조방법중존재적지가복잡외형제조곤난화내부미결구무법공제적결함,이차환가이통과유한원분석예선대지가적결구진행우화,이실현개선지가궤계강도등모사특수적요구.단시,유우조직기관적특수성화배외성급세포적점부조건,불단요종결구상개선지가,이차수요쾌속성형기술여구유조직상용성급가강해적재료상결합,사지가식입생물체후,세포능경호지증식화분화,촉진조직재생,수복결손조직.
@@@@BACKGROUND: Rapid Prototyping is a high-tech manufacturing technique based on material accumulation to be combined with computer, numerical control, laser and material technologies. OBJECTIVE: To review the application of rapid prototyping in the preparation of tissue engineering scaffolds. METHODS: The first author retrieved Wanfang, CNKI, and Elsevier Science Direct Online for articles about biomechanical ability and developmental prospect of scaffold materials, as wel as the application of rapid prototyping in the preparation of scaffold materials.RESULTS AND CONCLUSION: Rapid prototyping has become mature gradual y in the preparation of tissue engineering scaffolds. This technology can not only overcome the difficulty in shaping and internal microstructural control, but also optimize the scaffold structure via the finite element analysis, achieving some special requirements such as the improvement of mechanical strength. However, due to the particularity of tissue organ, and xenophobic sex and cel adhesion conditions, it is pre-requisite to combine rapid prototyping technology with biodegradable materials with histocompatibility in order to make the cells proliferation and differentiation better, promote tissue regeneration, and repair tissue defects.