中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2013年
8期
1473-1480
,共8页
生物材料%生物材料学术探讨%药物%缓释%聚乳酸%肿瘤%胶质瘤%结核%抗菌%抗病毒%5-氟尿嘧啶%阿霉素%表阿霉素%紫杉醇%盐酸氧氟沙星%阿奇霉素%替硝唑%异烟肼%利福平
生物材料%生物材料學術探討%藥物%緩釋%聚乳痠%腫瘤%膠質瘤%結覈%抗菌%抗病毒%5-氟尿嘧啶%阿黴素%錶阿黴素%紫杉醇%鹽痠氧氟沙星%阿奇黴素%替硝唑%異煙肼%利福平
생물재료%생물재료학술탐토%약물%완석%취유산%종류%효질류%결핵%항균%항병독%5-불뇨밀정%아매소%표아매소%자삼순%염산양불사성%아기매소%체초서%이연정%리복평
背景:聚乳酸共聚物复合药物缓释材料能够降低药物的毒副作用,延长药物作用时间,提高药物治疗效果,是目前药物研究的热点之一.目的:明确各种聚乳酸共聚物复合药物缓释材料的特征以及实验应用效果.方法:将不同种类的药物与聚乳酸进行共聚结合形成聚乳酸共聚物复合药物缓释材料,分析多种聚乳酸共聚物复合药物缓释材料的释药特征,并分析动物实验研究中聚乳酸共聚物复合缓释药物材料的治疗效果.结果与结论:研究发现多种治疗药物均可以与聚乳酸结合形成聚乳酸共聚物复合药物缓释材料系统,其中包括抗肿瘤类药物、抗菌、抗病毒类药物、抗结核类药物、心脑血管疾病防治类药物以及代谢类药物.这些药物与聚乳酸结合形成共聚物缓释系统后,可以延长药物作用时间,有效稳定血药浓度,达到靶向性治疗的作用,明显提高药物治疗作用效果.
揹景:聚乳痠共聚物複閤藥物緩釋材料能夠降低藥物的毒副作用,延長藥物作用時間,提高藥物治療效果,是目前藥物研究的熱點之一.目的:明確各種聚乳痠共聚物複閤藥物緩釋材料的特徵以及實驗應用效果.方法:將不同種類的藥物與聚乳痠進行共聚結閤形成聚乳痠共聚物複閤藥物緩釋材料,分析多種聚乳痠共聚物複閤藥物緩釋材料的釋藥特徵,併分析動物實驗研究中聚乳痠共聚物複閤緩釋藥物材料的治療效果.結果與結論:研究髮現多種治療藥物均可以與聚乳痠結閤形成聚乳痠共聚物複閤藥物緩釋材料繫統,其中包括抗腫瘤類藥物、抗菌、抗病毒類藥物、抗結覈類藥物、心腦血管疾病防治類藥物以及代謝類藥物.這些藥物與聚乳痠結閤形成共聚物緩釋繫統後,可以延長藥物作用時間,有效穩定血藥濃度,達到靶嚮性治療的作用,明顯提高藥物治療作用效果.
배경:취유산공취물복합약물완석재료능구강저약물적독부작용,연장약물작용시간,제고약물치료효과,시목전약물연구적열점지일.목적:명학각충취유산공취물복합약물완석재료적특정이급실험응용효과.방법:장불동충류적약물여취유산진행공취결합형성취유산공취물복합약물완석재료,분석다충취유산공취물복합약물완석재료적석약특정,병분석동물실험연구중취유산공취물복합완석약물재료적치료효과.결과여결론:연구발현다충치료약물균가이여취유산결합형성취유산공취물복합약물완석재료계통,기중포괄항종류류약물、항균、항병독류약물、항결핵류약물、심뇌혈관질병방치류약물이급대사류약물.저사약물여취유산결합형성공취물완석계통후,가이연장약물작용시간,유효은정혈약농도,체도파향성치료적작용,명현제고약물치료작용효과.
@@@@BACKGROUND: Polylactic acid copolymer composite sustained-release drug materials can reduce the toxic side effects of drugs, extend the action time and improve the effect of the drugs, and it is the hot spot of the drug research recently. OBJECTIVE: To identify the characteristics and experimental application of various polylactic acid copolymer composite sustained-release drug materials. METHODS: Different types of drugs were copolymerized with the polylactic acid to form the polylactic acid copolymer composite sustained-release drug materials, and the drug release characteristics and the treatment effect of various polylactic acid copolymer composite sustained-release drug materials in the animal experimental studies were analyzed. RESULTS AND CONCLUSION: Studies have found that many types of drug can be copolymerized with the polylactic acid and form the polylactic acid copolymer composite sustained-release drug material system, including the anti-tumor drugs, anti-bacterial drugs, anti-viral drugs, anti-tuberculosis drugs, drugs for the prevention and treatment of cardiovascular and cerebrovascular diseases and the metabolic drugs. The drugs above can prolong the action time, effectively stabilize the plasma concentration, obtain the role of targeted therapy and significantly improve the treatment effect after copolymerized with the polylactic acid and form the polylactic acid copolymer composite sustained-release drug material system.
