CAJ | 학술논문

背景:化疗药物缓释系统能够改善化疗药物对胃癌的治疗效果,是目前药物材料研究的热点.目的:评价不同缓释药物系统治疗胃癌的缓释性能及靶向作用效果.方法:通过不同的制备方法获得5-氟尿嘧啶聚乳酸缓释药物、5-氟尿嘧啶壳聚糖缓释药物、纳米活性炭吸附丝裂霉素缓释药物以及几丁糖顺铂缓释药物,并检测上述药物的缓释性能特征,同时明确上述缓释药物对胃癌的靶向作用以及对胃癌的治疗效果.结果与结论:5-氟尿嘧啶聚乳酸缓释药物、5-氟尿嘧啶壳聚糖缓释药物、纳米活性炭吸附丝裂霉素缓释药物以及几丁糖顺铂缓释药物具有良好的药物缓释性能,可以延长药物与肿瘤组织的作用时间,使化疗药物发挥更强的胃癌细胞抑制和杀伤作用,改善胃癌患者的预后,延长胃癌患者的生存.此外,采用腹腔灌注化疗药物的给药方式,可以进一步提高化疗药物对胃癌组织的杀伤作用.
배경:화료약물완석계통능구개선화료약물대위암적치료효과,시목전약물재료연구적열점.목적:평개불동완석약물계통치료위암적완석성능급파향작용효과.방법:통과불동적제비방법획득5-불뇨밀정취유산완석약물、5-불뇨밀정각취당완석약물、납미활성탄흡부사렬매소완석약물이급궤정당순박완석약물,병검측상술약물적완석성능특정,동시명학상술완석약물대위암적파향작용이급대위암적치료효과.결과여결론:5-불뇨밀정취유산완석약물、5-불뇨밀정각취당완석약물、납미활성탄흡부사렬매소완석약물이급궤정당순박완석약물구유량호적약물완석성능,가이연장약물여종류조직적작용시간,사화료약물발휘경강적위암세포억제화살상작용,개선위암환자적예후,연장위암환자적생존.차외,채용복강관주화료약물적급약방식,가이진일보제고화료약물대위암조직적살상작용.
@@@@BACKGROUND: The delivery system of chemotherapy drugs can improve the therapeutic effect of chemotherapy drugs on gastric cancer, and it is a hot spot of the research of drug materials. OBJECTIVE: To evaluate release properties and targeting effects of sustained-release drugs for the treatment of gastric cancer. METHODS: The 5-fluorouracil polylactic acid sustained-release drugs, 5-fluorouracil chitosan sustained-release drugs, nano-activated carbon mitomycin sustained-release drugs and chitosan cisplatin sustained-release drugs were prepared through different methods. Sustained-release performance and characteristics of the drugs above were detected, and the targeting effects and therapeutic effect of the drugs on gastric cancer were identified. RESULTS AND CONCLUSION: The 5-fluorouracil polylactic acid sustained-release drugs, 5-fluorouracil chitosan sustained-release drugs, nano-activated carbon mitomycin sustained-release drugs and chitosan cisplatin sustained-release drugs have good sustained-release properties which can prolong the effective time of drugs on tumor tissues, help the chemotherapy drugs play a stronger inhibition and kil ing effect on gastric cancer cells, improve prognosis and prolong the survival of patients with gastric cancer. In addition, the application of peritoneal perfusion of chemotherapy drugs can further improve the kil ing effect of chemotherapy drugs on gastric cancer tissues.