中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2013年
8期
1489-1496
,共8页
生物材料%生物材料学术探讨%抗肿瘤%缓释%药物%壳聚糖%细胞%纳米%去甲斑蝥素%阿霉素%表阿霉素%表柔比星%5-氟尿嘧啶%紫杉醇%叶酸
生物材料%生物材料學術探討%抗腫瘤%緩釋%藥物%殼聚糖%細胞%納米%去甲斑蝥素%阿黴素%錶阿黴素%錶柔比星%5-氟尿嘧啶%紫杉醇%葉痠
생물재료%생물재료학술탐토%항종류%완석%약물%각취당%세포%납미%거갑반모소%아매소%표아매소%표유비성%5-불뇨밀정%자삼순%협산
biomaterials%academic discussion of biomaterials%anti-tumor%sustained release%drugs%chitosan%cells%nanometer%norcantharidin%adriamycin%pharmorubicin%epirubicin%5-fluorouracil%paclitaxel%folic acid
背景:肿瘤严重危害人类的健康,应用有效的化学药物治疗具有重要的意义.目的:分析壳聚糖载药缓释系统抗肿瘤的作用机制及治疗效果.方法:分析壳聚糖抗肿瘤药物缓释材料释放药物机制以及抗肿瘤的作用机制,并分析壳聚糖及其衍生物负载多种抗肿瘤药物如阿霉素、表阿霉素、表柔比星、5-氟尿嘧啶、紫杉醇等的特征及抗肿瘤作用效果.结果与结论:壳聚糖抗肿瘤缓释药物材料具有良好的药物缓释性能以及抗肿瘤性能,能够负载各种常用的抗肿瘤药物,可以控制药物释放速率,延长药物作用时间,维持有效的药物浓度,降低药物的毒副作用,并且对肿瘤及组织器官具有靶向性作用,明显提高了化疗药物对肿瘤的治疗作用.
揹景:腫瘤嚴重危害人類的健康,應用有效的化學藥物治療具有重要的意義.目的:分析殼聚糖載藥緩釋繫統抗腫瘤的作用機製及治療效果.方法:分析殼聚糖抗腫瘤藥物緩釋材料釋放藥物機製以及抗腫瘤的作用機製,併分析殼聚糖及其衍生物負載多種抗腫瘤藥物如阿黴素、錶阿黴素、錶柔比星、5-氟尿嘧啶、紫杉醇等的特徵及抗腫瘤作用效果.結果與結論:殼聚糖抗腫瘤緩釋藥物材料具有良好的藥物緩釋性能以及抗腫瘤性能,能夠負載各種常用的抗腫瘤藥物,可以控製藥物釋放速率,延長藥物作用時間,維持有效的藥物濃度,降低藥物的毒副作用,併且對腫瘤及組織器官具有靶嚮性作用,明顯提高瞭化療藥物對腫瘤的治療作用.
배경:종류엄중위해인류적건강,응용유효적화학약물치료구유중요적의의.목적:분석각취당재약완석계통항종류적작용궤제급치료효과.방법:분석각취당항종류약물완석재료석방약물궤제이급항종류적작용궤제,병분석각취당급기연생물부재다충항종류약물여아매소、표아매소、표유비성、5-불뇨밀정、자삼순등적특정급항종류작용효과.결과여결론:각취당항종류완석약물재료구유량호적약물완석성능이급항종류성능,능구부재각충상용적항종류약물,가이공제약물석방속솔,연장약물작용시간,유지유효적약물농도,강저약물적독부작용,병차대종류급조직기관구유파향성작용,명현제고료화료약물대종류적치료작용.
@@@@BACKGROUND: Tumor is serious harmful to human health, and the application of effective chemical drug therapy has great significance. OBJECTIVE: To analyze the mechanism and the therapeutic effect of drug-loaded chitosan sustained-release system on the treatment of tumor. METHODS: The mechanism and the therapeutic effect of drug-loaded chitosan sustained-release system on the treatment of tumor was analyzed, as wel as the characteristics and anti-tumor effect of chitosan and various chitosan-loaded anti-tumor drugs, such as doxorubicin, epirubicin, epirubicin, 5-fluorouracil and paclitaxel. RESULTS AND CONCLUSION: Chitosan anti-tumor-sustained release drug materials have good drug release properties and anti-tumor properties, it can load variety of commonly used antitumor drugs, control the drug release rate, extend the drug action time, maintain the effective drug concentration and decrease the toxicity and side effects of drugs, it also has targeting effect on tumor and tissues and organs, and it can increase the therapeutic effect of chemotherapeutic drugs on tumor significantly.
