CAJ | 학술논문

生物材料%生物材料学术探讨%肝癌%靶向%5-氟尿嘧啶%丝裂霉素%表阿霉素%导管动脉化疗栓塞%肝动脉%门静脉%细胞%CT%血管造影%省级基金生物材料%生物材料學術探討%肝癌%靶嚮%5-氟尿嘧啶%絲裂黴素%錶阿黴素%導管動脈化療栓塞%肝動脈%門靜脈%細胞%CT%血管造影%省級基金
생물재료%생물재료학술탐토%간암%파향%5-불뇨밀정%사렬매소%표아매소%도관동맥화료전새%간동맥%문정맥%세포%CT%혈관조영%성급기금
biomaterials%academic discussion of biomaterials%liver cancer%target%5-fluorouracil%mitomycin%epirubicin%transcatheter arterial chemoembolization%hepatic artery%portal vein%cells%computed tomography%angiography%provincial grants-supported paper

背景:肝癌是常见的恶性肿瘤之一,选择有效的治疗药物及治疗方法具有重要的意义.目的:评价载体缓释化疗药物对肝癌的靶向治疗作用及效果.方法:分析临床常用的肝癌化疗药物5-氟尿嘧啶、丝裂霉素以及表阿霉素载体缓释系统对肝脏肿瘤的靶向性特征以及对肿瘤的抑制和杀伤作用.并观察总结海南省农垦总医院肿瘤内科163例中晚期肝癌患者应用化疗药物5-氟尿嘧啶、丝裂霉素、表阿霉素,同时采用导管动脉化疗栓塞辅助治疗的临床效果.结果与结论:5-氟尿嘧啶、丝裂霉素以及表阿霉素载体缓释系统通过不同的作用机制显示出对肝脏肿瘤的靶向性特征,并且对肝脏肿瘤具有较高的抑制和杀伤作用,减少药物用量,降低毒副作用,提高治疗效果.此外,治疗时辅助应用导管动脉化疗栓塞可以延长患者的生存期,提高肝癌的治疗效果.
배경:간암시상견적악성종류지일,선택유효적치료약물급치료방법구유중요적의의.목적:평개재체완석화료약물대간암적파향치료작용급효과.방법:분석림상상용적간암화료약물5-불뇨밀정、사렬매소이급표아매소재체완석계통대간장종류적파향성특정이급대종류적억제화살상작용.병관찰총결해남성농은총의원종류내과163례중만기간암환자응용화료약물5-불뇨밀정、사렬매소、표아매소,동시채용도관동맥화료전새보조치료적림상효과.결과여결론:5-불뇨밀정、사렬매소이급표아매소재체완석계통통과불동적작용궤제현시출대간장종류적파향성특정,병차대간장종류구유교고적억제화살상작용,감소약물용량,강저독부작용,제고치료효과.차외,치료시보조응용도관동맥화료전새가이연장환자적생존기,제고간암적치료효과.
@@@@BACKGROUND: Liver cancer is one of the common malignant tumor, and choosing the effective therapy and treatment method has great significance for the treatment of liver cancer. OBJECTIVE: To evaluate the targeting therapy effect of the carrier sustained-release chemotherapy drugs for the treatment of liver cancer. METHODS: The clinical commonly used liver cancer chemotherapy drugs included the 5-fluorouracil, mitomycin and epirubicin vector sustained-release system, and the tumor targeting characteristics and suppression and kil ing effect of these cancer chemotherapy drugs on the tumor were analyzed. A total of 163 patients with advanced liver cancer were selected from Department of Medical Oncology, Hainan Provincial Nong Ken Hospital. The patients were treated with 5-fluorouracil, mitomycin and epirubicin combined with the adjuvant treatment of transcatheter arterial chemoembolization, and then the clinical effect was observed. RESULTS AND CONCLUSION: 5-fluorouracil, mitomycin and epirubicin vector sustained release system show the targeting characteristics to liver tumor through different mechanisms, and have strong inhibiting and kil ing effect on liver tumors. And the cancer chemotherapy drugs can reduce the drug consumption, decrease the toxicity side effect and thus improve the therapeutic effect. In addition, the combination of transcatheter arterial chemoembolization can prolong the survival of the patients and improve the therapeutic effect of liver cancer.