CAJ | 학술논문

背景:正电子发射计算机断层显像(PET)从分子水平反映细胞代谢和功能变化,MRI 有更高的软组织对比度和空间分辨率,且无电磁辐射.近年来,随着多模式成像技术飞速发展,作为刚刚应用于临床的多模式分子成像技术,PET/MRI 融合显像可提供分子、形态与功能信息,有关研究已成为分子影像领域的关注焦点.目的:就目前 PET/MRI 研制存在的问题和进展情况做一综述,并展望其潜在的临床和科研价值.方法:由第一作者应用计算机检索 CNKI 数据库、Springerlink 数据库、Pubmed 数据库相关文献.检索时间范围:2000年1月至2012年6月.英文检索词:“PET/MRI”和“multimodality imaging or image fusion”,中文检索词:“分子影像学”和“图像融合”.选择内容与 PET/MRI 多模式成像相关的文章,同一领域文献则选择近期发表或发表在权威杂志文章,共纳入53篇文献.结果与结论:已有的研究成果表明,PET/MRI 较传统显像手段和其他成功的多模式成像技术,如PET/CT 和 SPECT/CT 有更多、更新的应用优势,并已积累临床前和初步临床应用的经验,PET/MRI具有广阔的发展空间,有望将分子影像技术的发展带入一个新的时代,为临床诊断掀开新的篇章.
배경:정전자발사계산궤단층현상(PET)종분자수평반영세포대사화공능변화,MRI 유경고적연조직대비도화공간분변솔,차무전자복사.근년래,수착다모식성상기술비속발전,작위강강응용우림상적다모식분자성상기술,PET/MRI 융합현상가제공분자、형태여공능신식,유관연구이성위분자영상영역적관주초점.목적:취목전 PET/MRI 연제존재적문제화진전정황주일종술,병전망기잠재적림상화과연개치.방법:유제일작자응용계산궤검색 CNKI 수거고、Springerlink 수거고、Pubmed 수거고상관문헌.검색시간범위:2000년1월지2012년6월.영문검색사:“PET/MRI”화“multimodality imaging or image fusion”,중문검색사:“분자영상학”화“도상융합”.선택내용여 PET/MRI 다모식성상상관적문장,동일영역문헌칙선택근기발표혹발표재권위잡지문장,공납입53편문헌.결과여결론:이유적연구성과표명,PET/MRI 교전통현상수단화기타성공적다모식성상기술,여PET/CT 화 SPECT/CT 유경다、경신적응용우세,병이적루림상전화초보림상응용적경험,PET/MRI구유엄활적발전공간,유망장분자영상기술적발전대입일개신적시대,위림상진단흔개신적편장.
BACKGROUND: Positron emission tomography can reflect the cel metabolism and functional changes of cells at the molecular level. Magnetic resonance imaging can obtain images with higher soft-tissue contrast and better spatial resolution without ionizing radiation. With the fast development of multimodality molecular imaging techniques, positron emission tomography/magnetic resonance imaging as a multimodality molecular imaging technique can provide the molecular, morphological and functional information, so its clinical application is an anticipating focus of medical molecular imaging.OBJECTIVE: To overview the progress and problems meet in the development of positron emission tomography/magnetic resonance imaging and to get a clear prospect of its potential clinical and scientific application. METHODS: The CNKI database, SpringerLink database and PubMed database were searched by the first author for the related articles from January 2000 to June 2012. The English key words were “PET/MRI” and“multimodality molecular imaging or image fusion”, and the Chinese key words were “molecular imaging” and“image fusion”. The articles related to positron emission tomography/magnetic resonance imaging multimodality molecular imaging technique were selected, and for the articles in the same field, those published recently or in the authorized journals were selected. A total of 53 articles were included. RESULTS AND CONCLUSION: From the existing research results, positron emission tomography/magnetic resonance imaging have more advantages over traditional and other multimodality imaging techniques such as positron emission tomography/computed tomography and single-photon emission computed tomography/computed tomography, as demonstrated by the pre-clinical studies and preliminary clinical experiences, and have broader development space. So it has capacity to bring the development of molecular imaging technique and clinical diagnosis into a new area.