CAJ | 학술논문

组织构建%组织构建学术探讨%骨细胞%破骨细胞%重建%应力感受%应力刺激%突触%骨吸收抑制%硬化蛋白%牙本质基质蛋白 1%综述文献組織構建%組織構建學術探討%骨細胞%破骨細胞%重建%應力感受%應力刺激%突觸%骨吸收抑製%硬化蛋白%牙本質基質蛋白 1%綜述文獻
조직구건%조직구건학술탐토%골세포%파골세포%중건%응력감수%응력자격%돌촉%골흡수억제%경화단백%아본질기질단백 1%종술문헌
tissue construction%tissue construction academic discussion%osteocytes%osteoclasts%reconstruction%stress feelings%stress stimuli%synapses%bone resorption inhibition%hardened protein%dentin matrix protein 1%review literature

背景:骨细胞在骨组织中形成遍布矿化骨基质的三维细胞网络,可以作为骨代谢重要的调节因子.目的:分析讨论骨细胞在骨重建过程中功能的研究进展.方法:应用计算机检索 PubMed 数据库、ELSEVIER 数据库1990年1月至2012年4月有关骨细胞功能及骨重建的文章,检索词“osteocytes,remodeling”.同时检索万方数据库1990年1月至2012年4月相关文章,检索词“骨细胞,骨重建”.选出有代表意义的41篇进行归纳总结,排除重复或类似的同一研究.结果与结论:骨细胞对于应力的感受与反应使得骨细胞在骨重建中发挥着重要的作用,包括骨重建的启动、骨吸收抑制以及骨形成的调节.研究表明骨细胞的突触可能作为应力造成细胞变形的直接感受器.实验证明骨细胞受应力刺激后可能激活 Wnt/Lrp 通路作为硬化蛋白的负调节因子,而硬化蛋白本身是骨形成的负调节因子,骨细胞在重建过程中可能还承担着控制骨基质填充速度的角色.
배경:골세포재골조직중형성편포광화골기질적삼유세포망락,가이작위골대사중요적조절인자.목적:분석토론골세포재골중건과정중공능적연구진전.방법:응용계산궤검색 PubMed 수거고、ELSEVIER 수거고1990년1월지2012년4월유관골세포공능급골중건적문장,검색사“osteocytes,remodeling”.동시검색만방수거고1990년1월지2012년4월상관문장,검색사“골세포,골중건”.선출유대표의의적41편진행귀납총결,배제중복혹유사적동일연구.결과여결론:골세포대우응력적감수여반응사득골세포재골중건중발휘착중요적작용,포괄골중건적계동、골흡수억제이급골형성적조절.연구표명골세포적돌촉가능작위응력조성세포변형적직접감수기.실험증명골세포수응력자격후가능격활 Wnt/Lrp 통로작위경화단백적부조절인자,이경화단백본신시골형성적부조절인자,골세포재중건과정중가능환승담착공제골기질전충속도적각색.
BACKGROUND: Osteocytes that form a three-dimensional cel ular network inside the mineralized bone matrix are a critical regulator of bone metabolism. OBJECTIVE: To explore the progress in studies of osteocytes effect on bong remodeling. METHODS: The articles on the role of osteocytes and bone remodeling were searched by computer in the PubMed and ELSEVIER databases from January 1990 to April 2012 using the key words of “osteocytes,remodeling”. Meanwhile, Wanfang database was retrieved to identify the related articles published between January 1990 and April 2012 with the keywords of “osteocytes, remodeling” in Chinese. After the ful texts on the subject were founded, 41 articles were chosen and summarized. Repetition and analogous researches were excluded. RESULTS AND CONCLUSION: Osteocytes that sense and response to mechanical stress play a critical role in bone remodeling, including initiating bone remodeling, inhibiting bone resorption and control ing bone formation. Studies have demonstrated that osteocyte synapses can serve as the direct receptor for stress-induced cel deformation. After stress stimulation, osteocytes can activate the Wnt/Lrp pathway serving as a negative regulator of hardened protein that is a negative regulator of bone formation, and osteocytes also play a role in the control of bone matrix fil ing during bone remodeling.