CAJ | 학술논문

生物材料%纳米生物材料%纳米羟基磷灰石%聚羟基丁酸戊酯/聚乙二醇%5-氟尿嘧啶%骨肿瘤%骨缺损%无机质%生物力学%骨密度%生物材料图片文章生物材料%納米生物材料%納米羥基燐灰石%聚羥基丁痠戊酯/聚乙二醇%5-氟尿嘧啶%骨腫瘤%骨缺損%無機質%生物力學%骨密度%生物材料圖片文章
생물재료%납미생물재료%납미간기린회석%취간기정산무지/취을이순%5-불뇨밀정%골종류%골결손%무궤질%생물역학%골밀도%생물재료도편문장
biomaterials%nanobiomaterials%nano-hydroxyapatite%poly(3-hydroxybutyrate-hydroxyvalerate)/polyethylene glycol%5-fluorouracil%bone tumors%bone defects%inorganic%biomechanics%bone density%biomaterial photographs-containing paper

背景:前期研究成功制备了纳米羟基磷灰石-聚羟基丁酸戊酯/聚乙二醇-5-氟尿嘧啶材料.目的:观察纳米羟基磷灰石-聚羟基丁酸戊酯/聚乙二醇-5-氟尿嘧啶的填充骨缺损和抗肿瘤作用.方法:取72只新西兰兔建立右膝关节 VX2骨肿瘤模型,切除部分胫骨形成骨缺损,且使骨缺损与肿瘤相邻,造模后随机分为实验组与对照组,分别于骨缺损处植入纳米羟基磷灰石-聚羟基丁酸戊酯/聚乙二醇-5-氟尿嘧啶与纳米羟基磷灰石-聚羟基丁酸戊酯/聚乙二醇人工骨.结果与结论:①无机质含量:两组均随时间的延长逐渐降低,尤以实验组明显.②X 射线检查:实验组术后24周材料体积较植入初期变小,肿瘤开始变小.对照植入材料体积始终无明显变化,肿瘤体积进行性增大.③生物力学检测:术后24周,实验组下肢标本最大扭转强度明显高于对照组(P <0.01).④骨密度检测:术后2-24周,两组均呈先减低后增加趋势,以实验组明显.⑤肿瘤体积变化:术后24周,实验组减小,对照组增加.表明纳米羟基磷灰石-聚羟基丁酸戊酯/聚乙二醇-5-氟尿嘧啶复合材料能很好填充骨缺损并有明显抑制肿瘤生长的作用.
배경:전기연구성공제비료납미간기린회석-취간기정산무지/취을이순-5-불뇨밀정재료.목적:관찰납미간기린회석-취간기정산무지/취을이순-5-불뇨밀정적전충골결손화항종류작용.방법:취72지신서란토건립우슬관절 VX2골종류모형,절제부분경골형성골결손,차사골결손여종류상린,조모후수궤분위실험조여대조조,분별우골결손처식입납미간기린회석-취간기정산무지/취을이순-5-불뇨밀정여납미간기린회석-취간기정산무지/취을이순인공골.결과여결론:①무궤질함량:량조균수시간적연장축점강저,우이실험조명현.②X 사선검사:실험조술후24주재료체적교식입초기변소,종류개시변소.대조식입재료체적시종무명현변화,종류체적진행성증대.③생물역학검측:술후24주,실험조하지표본최대뉴전강도명현고우대조조(P <0.01).④골밀도검측:술후2-24주,량조균정선감저후증가추세,이실험조명현.⑤종류체적변화:술후24주,실험조감소,대조조증가.표명납미간기린회석-취간기정산무지/취을이순-5-불뇨밀정복합재료능흔호전충골결손병유명현억제종류생장적작용.
BACKGROUND: Previous studies have successful y prepared nano-hydroxyapatite-poly(3-hydroxybutyrate-hydroxyvalerate)/polyethylene glycol-5-fluorouracil. OBJECTIVE: To discuss the effect of nano-hydroxyapatite-poly(3-hydroxybutyrate-hydroxyvalerate)/polyethylene glycol-5-fluorouracil composite on bone defect repair and against bone tumor. METHODS: Bone tumor models were induced by injection of VX2 carcinoma cellsuspension into the medul ary cavity of right tibias in 72 New Zealand white rabbits through the knee joints. Partial resection of the tibia was performed to form bone defects that were adjacent to bone tumors. After modeling, al the rabbits were randomized into experimental and control groups. Nano-hydroxyapatite-poly(3-hydroxybutyrate-hydroxyvalerate)/polyethylene glycol-5-fluorouracil and nano-hydroxyapatite-poly(3-hydroxybutyrate-hydroxyvalerate)/polyethylene glycol artificial bone were implanted into bone defects, respectively, in the experimental and control groups. RESULTS AND CONCLUSION: (1) Inorganic content was decreased gradual y in the two groups, especial y in the experimental group. (2) X-ray examination: At 24 weeks after implantation, the implant became smal er than that in the early stage after implantation. However, there were no changes in the implant volume in the control group, and tumor volume in the control group was enlarged progressively. (3) Biomechanical detection: At 24 weeks after implantation, the maximal torque of the lower limbs in the experimental group was significantly higher than that in the control group (P < 0.01). (4) Bone mineral density in the two groups was firstly decreased and then increased at 2-24 weeks after implantation. The changes in the bone mineral density of the experimental group were significant. (6) Tumor volume was decreased in the experimental group and increased in the control group at 24 weeks after implantation. These findings indicate that nano-hydroxyapatite-poly(3-hydroxybutyrate-hydroxyvalerate)/polyethylene glycol-5-fluorouracil can perfectly repair bone defects and exert a remarkable effect against tumor growth.