中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2013年
12期
2138-2144
,共7页
生物材料%纳米生物材料%拔牙%剩余牙槽嵴%纳米晶矿化胶原%骨形态发生蛋白 2%活性肽%新骨形成%拔牙窝%口腔生物材料%生物材料图片文章
生物材料%納米生物材料%拔牙%剩餘牙槽嵴%納米晶礦化膠原%骨形態髮生蛋白 2%活性肽%新骨形成%拔牙窩%口腔生物材料%生物材料圖片文章
생물재료%납미생물재료%발아%잉여아조척%납미정광화효원%골형태발생단백 2%활성태%신골형성%발아와%구강생물재료%생물재료도편문장
biomaterials%nanobiomaterials%tooth extraction%residual ridge%nanocrystal ine mineralized col agen%bone morphogenetic protein-2%bioactive peptides%bone formation%extraction sockets%oral biomaterials%biomaterial photographs-containing paper
背景:各种原因导致的牙齿拔除后都会造成剩余牙槽嵴的吸收,导致颌骨骨量不足,不利于患者后期接受义齿和种植牙的修复治疗.目的:通过建立大鼠拔牙后剩余牙槽嵴模型,观察纳米晶胶原基骨/活性肽 P17-骨形态发生蛋白2对拔牙窝修复及牙槽嵴吸收的影响.方法:将36只健康 SD 大鼠随机分为实验组、对照组和单纯材料组,均拔除右侧下颌中切牙,实验组在拔牙窝内即刻植入纳米晶胶原基骨/活性肽 P17-骨形态发生蛋白2材料,对照组在拔牙窝内植入纳米晶胶原基骨/骨形态发生蛋白2材料,单纯材料组在拔牙窝内植入纳米晶胶原基骨材料.结果与结论:①牙槽嵴的相对长度:术后2,4,8周,实验组与对照组均大于单纯材料组(P <0.05),实验组与对照组比较差异无显著性意义(P >0.05).②组织学观察结果:术后2,4,8周,实验组与对照组新生血管和新骨形成的速度和质量均优于单纯材料组.③新生骨面积占骨缺损面积的百分比:术后2,4,8周,各组随时间增长不断增加,实验组与对照组大于单纯材料组(P <0.05),对照组大于实验组.表明纳米晶胶原基骨/活性肽 P17-骨形态发生蛋白2具有良好的骨诱导能力,拔牙后即刻植入可促进拔牙创的愈合,延缓剩余牙槽嵴的吸收.
揹景:各種原因導緻的牙齒拔除後都會造成剩餘牙槽嵴的吸收,導緻頜骨骨量不足,不利于患者後期接受義齒和種植牙的脩複治療.目的:通過建立大鼠拔牙後剩餘牙槽嵴模型,觀察納米晶膠原基骨/活性肽 P17-骨形態髮生蛋白2對拔牙窩脩複及牙槽嵴吸收的影響.方法:將36隻健康 SD 大鼠隨機分為實驗組、對照組和單純材料組,均拔除右側下頜中切牙,實驗組在拔牙窩內即刻植入納米晶膠原基骨/活性肽 P17-骨形態髮生蛋白2材料,對照組在拔牙窩內植入納米晶膠原基骨/骨形態髮生蛋白2材料,單純材料組在拔牙窩內植入納米晶膠原基骨材料.結果與結論:①牙槽嵴的相對長度:術後2,4,8週,實驗組與對照組均大于單純材料組(P <0.05),實驗組與對照組比較差異無顯著性意義(P >0.05).②組織學觀察結果:術後2,4,8週,實驗組與對照組新生血管和新骨形成的速度和質量均優于單純材料組.③新生骨麵積佔骨缺損麵積的百分比:術後2,4,8週,各組隨時間增長不斷增加,實驗組與對照組大于單純材料組(P <0.05),對照組大于實驗組.錶明納米晶膠原基骨/活性肽 P17-骨形態髮生蛋白2具有良好的骨誘導能力,拔牙後即刻植入可促進拔牙創的愈閤,延緩剩餘牙槽嵴的吸收.
배경:각충원인도치적아치발제후도회조성잉여아조척적흡수,도치합골골량불족,불리우환자후기접수의치화충식아적수복치료.목적:통과건립대서발아후잉여아조척모형,관찰납미정효원기골/활성태 P17-골형태발생단백2대발아와수복급아조척흡수적영향.방법:장36지건강 SD 대서수궤분위실험조、대조조화단순재료조,균발제우측하합중절아,실험조재발아와내즉각식입납미정효원기골/활성태 P17-골형태발생단백2재료,대조조재발아와내식입납미정효원기골/골형태발생단백2재료,단순재료조재발아와내식입납미정효원기골재료.결과여결론:①아조척적상대장도:술후2,4,8주,실험조여대조조균대우단순재료조(P <0.05),실험조여대조조비교차이무현저성의의(P >0.05).②조직학관찰결과:술후2,4,8주,실험조여대조조신생혈관화신골형성적속도화질량균우우단순재료조.③신생골면적점골결손면적적백분비:술후2,4,8주,각조수시간증장불단증가,실험조여대조조대우단순재료조(P <0.05),대조조대우실험조.표명납미정효원기골/활성태 P17-골형태발생단백2구유량호적골유도능력,발아후즉각식입가촉진발아창적유합,연완잉여아조척적흡수.
BACKGROUND: Al reasons for tooth extraction are able to cause the alveolar ridge absorption, resulting in jaw bone deficiency, which is harmful to the denture and dental implant repair. OBJECTIVE: Through the establishment of an alveolar ridge model in rats after tooth extraction, to observe the effect of nano-hydroxyapatete/col agen/P17-bone morphogenetic protein-2 on tooth crypt repair and alveolar ridge absorption. METHODS: Thirty-six healthy Sprague-Dawley rats were randomly divided into experimental group, control group and simple material group, and each group had 12 rats. The right mandibular incisors were removed in al the rats. nano-hydroxyapatete/col agen/P17-bone morphogenetic protein-2, nano-hydroxyapatete/col agen/bone morphogenetic protein-2 and nano-hydroxyapatete/col agen were implanted into the tooth crypt of the three groups, respectively. RESULTS AND CONCLUSION: After 2, 4, 8 weeks, alveolar ridge relative length in the experimental group and the control group was more than that in the simple material group (P < 0.05),but there was no difference between the experimental and control groups (P > 0.05). After 2, 4, 8 weeks, the experimental group and the control group had better new blood vessels and new bone formation speed and quality than the simple material group. Percentage of new bone area accounting for bone defect area was increased with time after 2, 4, 8 weeks, which was higher in the experimental and control groups than the simple material group (P < 0.05) and higher in the control group than the experimental group. These findings indicate that nano-hydroxyapatete/col agen/P17-bone morphogenetic protein-2 material has good bone induction ability, and dental implant can promote the healing immediately after tooth extraction and delay alveolar ridge absorption.
