CAJ | 학술논문

背景:神经导管技术理论上采用生物或非生物材料预制成合适的管状支架,桥接神经断端两侧,在提供神经再生微环境的同时通过神经诱导、营养作用促进神经再生.目的:观察组织工程化神经导管修复外周神经损伤的临床效果.方法:选择24例陈旧性上肢神经损伤患者,以患者自愿原则分2组治疗:试验组采用组织工程化神经导管修复,对照组采用自体周围体表感觉神经移植修复.治疗后随访6个月观察患者肢体神经损伤功能修复效果.结果与结论:随访6个月后,两组肢体远端感觉运动功能与目测类比疼痛评分均较治疗前改善(P <0.05),且试验组效果更好(P <0.05);两组损伤侧感觉与运动神经传导速度均较治疗前改善(P <0.05),且两组间差异无显著性意义.说明组织工程化神经导管材料符合神经修复导管支架的要求,临床应用疗效肯定.
배경:신경도관기술이론상채용생물혹비생물재료예제성합괄적관상지가,교접신경단단량측,재제공신경재생미배경적동시통과신경유도、영양작용촉진신경재생.목적:관찰조직공정화신경도관수복외주신경손상적림상효과.방법:선택24례진구성상지신경손상환자,이환자자원원칙분2조치료:시험조채용조직공정화신경도관수복,대조조채용자체주위체표감각신경이식수복.치료후수방6개월관찰환자지체신경손상공능수복효과.결과여결론:수방6개월후,량조지체원단감각운동공능여목측류비동통평분균교치료전개선(P <0.05),차시험조효과경호(P <0.05);량조손상측감각여운동신경전도속도균교치료전개선(P <0.05),차량조간차이무현저성의의.설명조직공정화신경도관재료부합신경수복도관지가적요구,림상응용료효긍정.
BACKGROUND: Theoretical y, nerve conduit technology uses the biological or non-biological materials to prefabricate suitable tubular stent to bridge the nerve ends on both sides. And it can promote the nerve regeneration through neural induction and nutrition under the nerve regeneration microenvironment. OBJECTIVE: To observe the clinical effects of tissue-engineered nerve conduits for repairing peripheral nerve damage. METHODS: Twenty-four patients with old upper extremity nerve damage were selected, and divided into two groups for the treatment according to voluntary principle. The patients in the experimental group were repaired with tissue-engineered nerve conduits, and those in the control group were repaired with autologous surrounding surface sensory nerve transplantation. Al the patients were fol owed-up for 6 months after treatment to observe the repairing functional effect of limb nerve damage.RESULTS AND CONCLUSION: After fol owed-up for 6 months, the limb distal sensory motor function and visual analogue scale scores of the limbs in the two groups were improved compared with those before treatment (P <0.05), and the experimental group showed better effects (P < 0.05); the sensory and motor nerve conduction velocity of the damaged side in the two groups were improved compared with those before treatment (P < 0.05), and there was no significant difference between the two groups. It indicates that tissue-engineered nerve conduit materials can meet the requirements of nerve repair conduit stent and the clinical application is effective.