CAJ | 학술논문

生物材料%生物材料学术探讨%缺血性脑卒中%血管内支架%介入治疗%血管内成形%脑血管疾病%金属支架%不锈钢%记忆合金%涂层支架%覆膜支架%药物洗脱支架%生物可降解支架%细胞种植支架生物材料%生物材料學術探討%缺血性腦卒中%血管內支架%介入治療%血管內成形%腦血管疾病%金屬支架%不鏽鋼%記憶閤金%塗層支架%覆膜支架%藥物洗脫支架%生物可降解支架%細胞種植支架
생물재료%생물재료학술탐토%결혈성뇌졸중%혈관내지가%개입치료%혈관내성형%뇌혈관질병%금속지가%불수강%기억합금%도층지가%복막지가%약물세탈지가%생물가강해지가%세포충식지가

背景:新型血管内支架材料是目前脑血管疾病介入治疗的研究热点.目的:分析血管内支架材料学特征及缺血性脑卒中治疗效果.方法:第一作者于2012年12月应用计算机检索数据库的相关文章,中文检索词为“缺血性脑卒中;血管内支架;支架材料;介入治疗”,检索时间范围在2003至2012年,共检索到相关文献120篇,符合纳入标准并用于分析的文献24篇.结果与结论:①金属裸支架在血液中长期存放有腐蚀、金属离子溶出和凝血性等现象,为解决金属材料存在的问题,可以通过金属支架表面改性来处理,提高金属材料的血液相溶性.②药物支架是将治疗药物涂于支架表面,使药物能够持续并高浓度的释放,防止支架置入后再狭窄.③覆膜血管内支架是在金属支架外表覆以可降解或不可降解的聚合物薄膜,抑制血管内皮增生,对血管平滑肌细胞具有良好的生物相容性,可以预防血管支架置入后再狭窄.血管内支架治疗可以降低缺血性脑卒中的风险,是一种安全有效的治疗手段,同时还可以改善缺血性脑病患者的认知功能障碍.基因及细胞种植支架材料在防治脑血管介入后再狭窄方面也具有一定优势,是血管内支架材料研究的新方向.
배경:신형혈관내지가재료시목전뇌혈관질병개입치료적연구열점.목적:분석혈관내지가재료학특정급결혈성뇌졸중치료효과.방법:제일작자우2012년12월응용계산궤검색수거고적상관문장,중문검색사위“결혈성뇌졸중;혈관내지가;지가재료;개입치료”,검색시간범위재2003지2012년,공검색도상관문헌120편,부합납입표준병용우분석적문헌24편.결과여결론:①금속라지가재혈액중장기존방유부식、금속리자용출화응혈성등현상,위해결금속재료존재적문제,가이통과금속지가표면개성래처리,제고금속재료적혈액상용성.②약물지가시장치료약물도우지가표면,사약물능구지속병고농도적석방,방지지가치입후재협착.③복막혈관내지가시재금속지가외표복이가강해혹불가강해적취합물박막,억제혈관내피증생,대혈관평활기세포구유량호적생물상용성,가이예방혈관지가치입후재협착.혈관내지가치료가이강저결혈성뇌졸중적풍험,시일충안전유효적치료수단,동시환가이개선결혈성뇌병환자적인지공능장애.기인급세포충식지가재료재방치뇌혈관개입후재협착방면야구유일정우세,시혈관내지가재료연구적신방향.
BACKGROUND: Novel endovascular stent materials have become the research hot spot in the treatment of ischemic stroke. OBJECTIVE: To analyze the features of endovascular stent materials and the treatment effect on ischemic stroke. METHODS: Related databases were searched by the first author with computer at December 2012 for the related articles published from 2003 to 2012. The Chinese key words were “ischemic stroke, endovascular stent, stent material, interventional treatment”. A total of 120 articles were screened out, and 24 articles were included for the final review according to the inclusion criteria. RESULTS AND CONCLUSION: Long-term storage of bare-metal stents in the blood may lead to corrosion, metal ions dissolution and coagulation; the surface modification of the metal material could be used to solve the problem of metal material storage in order to improve the blood compatibility of the metal materials. Therapeutic drugs were coated on the surface of stent which can help the drugs release with high concentration continuously, and this method can inhibit restenosis after stent implantation. Film-covered endovascular stent was covered with degradable or non-degradable polymer films on the surface of metal stent in order to inhibit the vascular endothelial proliferation and restenosis after stent implantation, and the film-covered endovascular stent could promote the biocompatibility of vascular smooth muscle cells. Endovascular stent is a safe and effective treatment method to reduce the risk of ischemic stroke, and it can also improve the cognitive dysfunction of the patients with ischemic encephalopathy. Gene and cel cultivation scaffold material has certain advantages in the prevention and treatment of restenosis after vascular intervention, which is the new direction for the research of endovascular stent materials.