化工技术与开发
化工技術與開髮
화공기술여개발
TECHNOLOGY & DVELOPMENT OF CHEMICAL INDUSTRY
2013年
3期
9-11
,共3页
长春胺%长春西汀%合成%氯化亚砜
長春胺%長春西汀%閤成%氯化亞砜
장춘알%장춘서정%합성%록화아풍
vincamine%vinpocetine%synthesis%sulfoxide chloride
提出了一种新的长春西汀合成方法,并对反应条件进行了优化.长春胺(2)经氯化亚砜脱水得到阿扑长春胺(3),再经氢氧化钠水解得到阿扑长春胺酸(4),最后在经氯化亚砜和乙醇酯化得到长春西汀(1).经此方法,长春西汀合成总收率达82.8%,纯度达99.5%.通过1H-NMR,13C-NMR,EI-MS对产物结构进行了确证.
提齣瞭一種新的長春西汀閤成方法,併對反應條件進行瞭優化.長春胺(2)經氯化亞砜脫水得到阿撲長春胺(3),再經氫氧化鈉水解得到阿撲長春胺痠(4),最後在經氯化亞砜和乙醇酯化得到長春西汀(1).經此方法,長春西汀閤成總收率達82.8%,純度達99.5%.通過1H-NMR,13C-NMR,EI-MS對產物結構進行瞭確證.
제출료일충신적장춘서정합성방법,병대반응조건진행료우화.장춘알(2)경록화아풍탈수득도아복장춘알(3),재경경양화납수해득도아복장춘알산(4),최후재경록화아풍화을순지화득도장춘서정(1).경차방법,장춘서정합성총수솔체82.8%,순도체99.5%.통과1H-NMR,13C-NMR,EI-MS대산물결구진행료학증.
@@@@A novel synthesis method of vinpocetine was proposed. The influence factors of each step were investigated and the reaction conditions were optimized. apovincamine (3) was produced from vincamine (2) by dehydration under sulfoxide chloride. The raw material apovincamine acid (4) was produced from apovincamine by sodium hydroxide.vinpocetine (1) was obtained from apovincamine acid by esterification.The yield and purity of vinpocetine were 82.8% and 99.5%, respectively. The structure of the product was identified by 1H-NMR, 13C-NMR and EI-MS.
