CAJ | 학술논문

转化医学是近年来医学领域中出现的一个新概念,旨在在基础研究和临床医疗之间建立更紧密的联系.富含鸟嘌呤(G)核苷酸序列形成的稳定G-四链体与人类重大疾病如肿瘤、神经退行性疾病密切相关,已成为转化医学研究中的一个重要方向.在端粒序列,G-四链体的形成和稳定可以抑制端粒酶活性,因此研发能稳定G-四链体结构的配体对抗肿瘤药物开发具有重大意义.此外,近年来神经退行性疾病中G-四链体的研究也取得重要进展.对与G-四链体相关的抗肿瘤药物研发和神经退行性疾病研究进行简要的总结.
전화의학시근년래의학영역중출현적일개신개념,지재재기출연구화림상의료지간건립경긴밀적련계.부함조표령(G)핵감산서렬형성적은정G-사련체여인류중대질병여종류、신경퇴행성질병밀절상관,이성위전화의학연구중적일개중요방향.재단립서렬,G-사련체적형성화은정가이억제단립매활성,인차연발능은정G-사련체결구적배체대항종류약물개발구유중대의의.차외,근년래신경퇴행성질병중G-사련체적연구야취득중요진전.대여G-사련체상관적항종류약물연발화신경퇴행성질병연구진행간요적총결.
@@@@In the last decade, translational medicine came into the limelight, aiming to bridge the gap between basic research and clinical application. The association of G-quadruplex with life-threating and debilitating diseases is an emerging topic in translational medicine. Since the formation of G-quadruplex can inhibit telomerase activity, the ligands that can stabilize G-quadruplex have great significance for cancer therapeutics. In addition, growing evidence suggests the implication of quadruplex in neurodegenerative diseases. In this review, the research of G-quadruplex in the fields of anti-tumor drugs and neurodegenerative diseases is discussed.