CAJ | 학술논문

目的研究6-氟硫色满酮Mannich碱对乙酰胆碱酯酶的抑制活性及作用类型.方法在体外采用Ellman方法对6-氟硫色满酮Mannich碱进行乙酰胆碱酯酶抑制实验和动力学实验.结果该化合物浓度为10-6mol/L时对乙酰胆碱酯酶的抑制率是51%,活性优于对照组利伐司替明,动力学实验初步证明是混合型竞争抑制.结论6-氟硫色满酮Mannich碱作为乙酰胆碱酯酶抑制剂具有进一步研究价值.
목적연구6-불류색만동Mannich감대을선담감지매적억제활성급작용류형.방법재체외채용Ellman방법대6-불류색만동Mannich감진행을선담감지매억제실험화동역학실험.결과해화합물농도위10-6mol/L시대을선담감지매적억제솔시51%,활성우우대조조리벌사체명,동역학실험초보증명시혼합형경쟁억제.결론6-불류색만동Mannich감작위을선담감지매억제제구유진일보연구개치.
@@@@Objective To study the inhibition activity and kinetics style of 6-fluorothiochromanone Mannich bases to acetylcholinesterase. Methods The inhibition and kinetics tests of 6-fluorothiochromanone Mannich bases to acetylcholinesterase were carried out by Ellman methods in vitro. Results The inhibition ratio of acetylcholinesterase was 51% when the concentration of this compound was 10-6mol/L, its inhibitive activity was better than Rivastigmine and primary kinetics experiments proved to be a mixed type of inhibition. conclusion 6-fluorothiochromanones Mannich bases are worthy for further research in acetylcholinesterase inhibitors.