CAJ | 학술논문

目的观察升阳益胃法对类风湿关节炎(RA)治疗过程中增效减毒的作用.方法选择诊断明确的150例类风湿关节炎患者,随机分为对照组75例、治疗组75例,均给予甲氨蝶呤、尼美舒利、甲泼尼龙口服,治疗组加用升阳益胃汤加减,对照组加用泮托拉唑钠胶囊,观察90d后对两组胃黏膜损伤及上消化道症状发生率进行比较,并分别在治疗前及治疗后30 d、治疗后90 d观察患者的ALT、ESR、CRP.结果治疗90 d后,治疗组胃黏膜损伤及上消化道症状发生率明显低于对照组,两组差异有统计学意义(P<0.05);两组治疗前后ALT、ESR及CRP比较,治疗组明显好于对照组,差异均有统计学意义(P<0.05).结论升阳益胃汤能有效防治RA治疗过程中出现的消化系统副作用,同时对类风湿关节炎在改善症状、控制疾病进展等方面具有较好的疗效.
목적관찰승양익위법대류풍습관절염(RA)치료과정중증효감독적작용.방법선택진단명학적150례류풍습관절염환자,수궤분위대조조75례、치료조75례,균급여갑안접령、니미서리、갑발니룡구복,치료조가용승양익위탕가감,대조조가용반탁랍서납효낭,관찰90d후대량조위점막손상급상소화도증상발생솔진행비교,병분별재치료전급치료후30 d、치료후90 d관찰환자적ALT、ESR、CRP.결과치료90 d후,치료조위점막손상급상소화도증상발생솔명현저우대조조,량조차이유통계학의의(P<0.05);량조치료전후ALT、ESR급CRP비교,치료조명현호우대조조,차이균유통계학의의(P<0.05).결론승양익위탕능유효방치RA치료과정중출현적소화계통부작용,동시대류풍습관절염재개선증상、공제질병진전등방면구유교호적료효.
@@@@Objective To observe the process of treatment and the role of attenuated effects in the rheumatoid arthritis (RA) treatment with Shengyangyiwei method. Methods 150 patients with RA were randomly divided into two groups. 75 patients in the control group while 75 patients in the treatment group. Both groups were treated with Methotrexate Nimesulide and methylprsdnisone, while the former was added with pantoprazole sodium capsules, and the later was added with Shengyangyiwei Tang treatment. The gastric mucosal injury and gastrointestinal symptoms were observed respectively before treatment and after treatment for 30 d and 90 d. ALT、ESR、CRP of the patients were observed after treating for 30 d and 90 d. Results After 90days’ treatment, the gastric mucosal injury and gastrointestinal symptoms in the patients of the experimental group were significantly lower than that of the control group.Therefore, the differences of the total efficiency in both groups were statistically significant. (With P<0.05). As for ALT, ESR and CRP comparison, the results of the treatment group was significantly better than that of the control group, the differences were significant (P<0.05). conclusion The Shengyangyiwei Tang can effectively prevent and control the digestive side effects in RA therapy and with significant treatment effects, at the same time it has good curative effects to improve symptoms, control the disease progress etc.