CAJ | 학술논문

2-甲基苯并咪唑是重要的医药及染料中间体.以邻苯二胺与乙酸为原料,微波促进001 H型树脂催化合成了2-甲基苯并咪唑.通过单因素实验考察了微波功率、反应时间、原料质量配比、树脂用量、树脂重复使用对2-甲基苯并咪唑合成收率的影响.结果发现,当微波功率为455 W、树脂用量0.5 g、反应时间为30 min、邻苯二胺用量1.08 g、乙酸用量3.24 g时收率最高,可达84.8%.树脂重复使用可行性的研究表明,树脂重复使用两次后,2-甲基苯并咪唑收率从84.8%下降66.7%.结果表明相比于2-甲基苯并咪唑的传统合成方法,具有产率高、工艺操作简单、环境污染效应小等优点,不足之处在于催化剂重复使用性较差,需做进一步的研究工作.
2-갑기분병미서시중요적의약급염료중간체.이린분이알여을산위원료,미파촉진001 H형수지최화합성료2-갑기분병미서.통과단인소실험고찰료미파공솔、반응시간、원료질량배비、수지용량、수지중복사용대2-갑기분병미서합성수솔적영향.결과발현,당미파공솔위455 W、수지용량0.5 g、반응시간위30 min、린분이알용량1.08 g、을산용량3.24 g시수솔최고,가체84.8%.수지중복사용가행성적연구표명,수지중복사용량차후,2-갑기분병미서수솔종84.8%하강66.7%.결과표명상비우2-갑기분병미서적전통합성방법,구유산솔고、공예조작간단、배경오염효응소등우점,불족지처재우최화제중복사용성교차,수주진일보적연구공작.
2-methyl benzimidazole,an important medicine and dye intermediate,was synthesized under microwave irradiation using diaminobenzene and acetic acid as raw materials and catalyzed by 001 H resin. The effects of microwave power,reaction time,mass ratio of raw materials,dose of resin and the reusage of 001 H resin on the yield of 2-methyl benzimidazole were investigated by single factor experiment. The results showed that the highest yield reached 84.8% under the optimum reaction conditions:microwave power 455 W,001 H resin 0.5 g,reaction time 30 min,diaminobenzene 1.08 g, and acetic acid 3.24 g. The study on the reusage of 001 H resin indicated that the yield of 2-methyl benzimidazole decreased from 84.8% to 66.7% after 001 H resin was used for three times. Compared with the traditional synthesis methods of 2-methyl benzimidazole,the method in this work has many advantages,such as higher yield,simpler process and less environmental pollution,but poor reusage of 001 H resin,which needs further research.