CAJ | 학술논문

目的:比较鲑降钙素、阿法骨化醇、碳酸钙联合应用与单用鲑降钙素治疗骨质疏松性股骨粗隆间骨折的临床疗效.方法:将80例行闭合复位PFNA内固定术治疗的骨质疏松性股骨粗隆间骨折患者,随机分为实验组及对照组.分别给予肌注鲑降钙素+口服阿法骨化醇和碳酸钙和单纯肌注鲑降钙素.治疗6个月及1年后测定骨密度值及观察骨折愈合时间并进行比较.结果:实验组治疗6个月和1年后腰椎和股骨颈,Ward三角及大转子4个部位BMD较对照组均显著上升(P<0.05).实验组与对照组比较,骨折愈合时间有显著性差异.结论:闭合复位PFNA内固定术治疗骨质疏松性股骨粗隆间骨折后,给予肌注鲑降钙素+口服阿法骨化醇和钙剂可显著提高患者的骨密度,缩短骨折的愈合时间,明显优于单纯给予肌注鲑降钙素的疗效.
목적:비교해강개소、아법골화순、탄산개연합응용여단용해강개소치료골질소송성고골조륭간골절적림상료효.방법:장80례행폐합복위PFNA내고정술치료적골질소송성고골조륭간골절환자,수궤분위실험조급대조조.분별급여기주해강개소+구복아법골화순화탄산개화단순기주해강개소.치료6개월급1년후측정골밀도치급관찰골절유합시간병진행비교.결과:실험조치료6개월화1년후요추화고골경,Ward삼각급대전자4개부위BMD교대조조균현저상승(P<0.05).실험조여대조조비교,골절유합시간유현저성차이.결론:폐합복위PFNA내고정술치료골질소송성고골조륭간골절후,급여기주해강개소+구복아법골화순화개제가현저제고환자적골밀도,축단골절적유합시간,명현우우단순급여기주해강개소적료효.
@@@@Objective:To study the clinical efficacy of a monotherapy of salmon calcitonin or a combination therapy of salmon calcitonin with alfacalcidol and calcium carbonate on osteoporotic intertrochanteric fracture. Methods:Eighty patients with osteoporotic intertrochanteric fractures who received a reduction and internal fixation with PFNA were randomly divided into either experimental group or control one. Patients in experimental group were administrated with intramuscular salmon calcitonin plus oral alfacalcidol and calcium carbonate while only intramuscular salmon calcitonin was given in control group. BMD was measured again after 6 months or 1 year treatment, and fracture healing time was observed. The obtained data were statistically analyzed. Results:BMD of lumbar spine, neck of femur, trochiter and Ward’s triangular area were more significantly increased in experimental group than in control group (P<0.05). The comparisons of fracture healing time between two groups showed significant differences. Conclusion:After closed reduction and internal fixation of PFNA in osteoporotic intertrochanteric fracture, combination therapy of intramuscular salmon calcitonin plus oral alfacalcidol and calcium carbonate can significantly improve the patient’s bone mineral density, shorten the healing time of fractures as compared with monotherapy of intramuscular salmon calcitonin.