CAJ | 학술논문

目的测定慢性乙型肝炎(CHB)患者外周血 CD4+ CD25+调节性 T 细胞(Treg)的水平并探讨其临床意义.方法流式细胞术检测40例慢性乙型病毒性肝炎患者(根据 B 超将其分为2组,其中 B 超提示慢性肝病改变的 CHB 慢性肝病组20例,提示肝硬化改变的 CHB 肝硬化组20例),20例健康对照组(Nc)对照外周血中 CD4+ CD25+ Treg 的变化.结果外周血中 CD4+ CD25+ Treg 占 CD4淋巴细胞的比例在 CHB 慢性肝病组为(12.00±1.47)%,CHB 肝硬化组为(11.14±1.07)%,与 NC 组(9.65±1.01)%相比差异有显著性(P <0.05),CHB 慢性肝病组与 CHB 肝硬化组间比较差异无显著性(P >0.05).结论 Treg 与 CHB 患者体内存在持续HBV 感染关系密切,而是否参与乙肝后肝硬化的发病机制需要深入研究.
목적측정만성을형간염(CHB)환자외주혈 CD4+ CD25+조절성 T 세포(Treg)적수평병탐토기림상의의.방법류식세포술검측40례만성을형병독성간염환자(근거 B 초장기분위2조,기중 B 초제시만성간병개변적 CHB 만성간병조20례,제시간경화개변적 CHB 간경화조20례),20례건강대조조(Nc)대조외주혈중 CD4+ CD25+ Treg 적변화.결과외주혈중 CD4+ CD25+ Treg 점 CD4림파세포적비례재 CHB 만성간병조위(12.00±1.47)%,CHB 간경화조위(11.14±1.07)%,여 NC 조(9.65±1.01)%상비차이유현저성(P <0.05),CHB 만성간병조여 CHB 간경화조간비교차이무현저성(P >0.05).결론 Treg 여 CHB 환자체내존재지속HBV 감염관계밀절,이시부삼여을간후간경화적발병궤제수요심입연구.
@@@@ Objective To determinate CD4+ CD25+regulatory T cells(Treg) levels of patients with chronic hepatitis B(CHB) in peripheral blood and to explore its clinical significance .Methods Flow cytometry detected 40 pa-tients with chronic hepatitis B patients (Be divided into two groups according to B -mode ultrasound,20 patients with chronic liver disease changes in B -mode ultrasound,20 patients with liver cirrhosis in B-mode ultrasound were assayed ). Twenty healthy subjects were used as control .Results The proportion of peripheral blood CD4+ CD25 CD4 lymphocytes in CHB chronic liver disease group presented (12.00 ±1.47)%,while the liver cirrhosis patients presented(11.14 ±1.07)%,which were both higher than those (9.65 ±1.01)% of the controls(P <0.05),there was no significant difference between chronic hepatitis B and chronic hepatitis B cirrhosis group (P >0.05).Conclusion These results indicate that the CD4+ CD25+ Treg plays a role in the persistent HBV infection ,and whether to participate in the hepatitis B cirrhosis pathogenesis requires in -depth study.+ Treg accounted