CAJ | 학술논문

背景:骨髓间充质干细胞具有多向分化潜能,对肝脏疾病、神经系统疾病、肺脏疾病、肾脏疾病的治疗都显示出其优越性,对心血管疾病治疗的研究也日益增多.目的:对骨髓间充质干细胞在心血管疾病中的应用以及治疗心血管疾病的机制进行综述.方法:应用计算机检索CNKI和Pubmed数据库中1985年1月至2009年12月关于骨髓间充质干细胞治疗心血管疾病的文章,在标题和中以“骨髓间充质干细胞,细胞移植,治疗,心血管疾病”或“bone marrow mesenchymal stem cel s,cel s transplant,therapy,cardiovascular disease”为检索词进行检索,最终纳入42篇文献进行综述.结果与结论:众多的研究表明骨髓间充质干细胞可以在梗死的心肌中分化形成有功能活性的心肌、血管内皮等组织,改善心脏的功能,干细胞移植在治疗心血管疾病方面已表现出传统治疗方法所无可比拟的优越性.
배경:골수간충질간세포구유다향분화잠능,대간장질병、신경계통질병、폐장질병、신장질병적치료도현시출기우월성,대심혈관질병치료적연구야일익증다.목적:대골수간충질간세포재심혈관질병중적응용이급치료심혈관질병적궤제진행종술.방법:응용계산궤검색CNKI화Pubmed수거고중1985년1월지2009년12월관우골수간충질간세포치료심혈관질병적문장,재표제화중이“골수간충질간세포,세포이식,치료,심혈관질병”혹“bone marrow mesenchymal stem cel s,cel s transplant,therapy,cardiovascular disease”위검색사진행검색,최종납입42편문헌진행종술.결과여결론:음다적연구표명골수간충질간세포가이재경사적심기중분화형성유공능활성적심기、혈관내피등조직,개선심장적공능,간세포이식재치료심혈관질병방면이표현출전통치료방법소무가비의적우월성.
BACKGROUND:Bone marrow mesenchymal stem cel s exhibit the capacity of multi-lineage differentiation and show advantages in treatment of liver disease, nervous system disease, lung disease and kidney disease. There are increasing studies regarding treatment of cardiovascular diseases. OBJECTIVE:To review the application of bone marrow mesenchymal stem cel s in treatment of cardiovascular disease and the underlying mechanism. METHODS:A computer-based online retrieval was performed to search papers describing bone marrow mesenchymal stem cel s for treatment of cardiovascular diseases published during 1985-01/2009-12 in CNKI and PubMed databases. The key words are bone marrow mesenchymal stem cel s, cel s transplant, therapy, cardiovascular disease. Forty-two papers were included in the final analysis. RESULTS AND CONCLUSION:A large number of studies have demonstrated that bone marrow mesenchymal stem cel s can differentiate into functional cardiac tissue and vascular endothelial tissue in infarct tissue and improve cardiac function. Bone marrow mesenchymal stem cel s show superiority over conventional therapy in the treatment of cardiovascular diseases.