中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2013年
1期
118-123
,共6页
范子扬%白金宝%王辉%郄红征%邓新生%胡莹%梁海生%王龙飞%王帅%刘增亮
範子颺%白金寶%王輝%郄紅徵%鄧新生%鬍瑩%樑海生%王龍飛%王帥%劉增亮
범자양%백금보%왕휘%극홍정%산신생%호형%량해생%왕룡비%왕수%류증량
干细胞%干细胞综述%骨髓间充质干细胞%胰岛细胞%糖尿病
榦細胞%榦細胞綜述%骨髓間充質榦細胞%胰島細胞%糖尿病
간세포%간세포종술%골수간충질간세포%이도세포%당뇨병
stem cells%stem cell review%bone marrow mesenchymal stem cells%islet cell%diabetes mellitus
背景:研究发现,骨髓间充质干细胞移植入糖尿病大鼠后能够降低其血糖.目的:综述骨髓间充质干细胞在促进胰岛再生方面的作用与研究现状.方法:应用计算机检索2003年7月至2011年12月PubMed数据库相关文章,检索词为“bone marrow derive mesenchymal stem cel ,islet cel s”,并限定文章语言种类为English.同时计算机检索2003年7月至2011年12月万方数据库相关文章,检索词为“骨髓间充质干细胞,胰岛细胞”,并限定文章语言种类为中文.最终纳入符合标准的文献25篇.结果与结论:目前,移植胰岛治疗糖尿病已取得良好疗效,但由于胰岛来源匮乏和异种或异体来源的胰岛引起免疫排斥反应而难以使众多糖尿患者受益.骨髓间充质干细胞取材方便,容易进行体外分离、培养和纯化,且具有多向分化潜能.若将骨髓间充质干细胞诱导分化为胰岛细胞,可望解决胰岛细胞来源和免疫排斥问题.文章对骨髓间充质干细胞分化为胰岛细胞治疗糖尿病的研究进展进行综述,并指出了存在问题和今后的研究方向.
揹景:研究髮現,骨髓間充質榦細胞移植入糖尿病大鼠後能夠降低其血糖.目的:綜述骨髓間充質榦細胞在促進胰島再生方麵的作用與研究現狀.方法:應用計算機檢索2003年7月至2011年12月PubMed數據庫相關文章,檢索詞為“bone marrow derive mesenchymal stem cel ,islet cel s”,併限定文章語言種類為English.同時計算機檢索2003年7月至2011年12月萬方數據庫相關文章,檢索詞為“骨髓間充質榦細胞,胰島細胞”,併限定文章語言種類為中文.最終納入符閤標準的文獻25篇.結果與結論:目前,移植胰島治療糖尿病已取得良好療效,但由于胰島來源匱乏和異種或異體來源的胰島引起免疫排斥反應而難以使衆多糖尿患者受益.骨髓間充質榦細胞取材方便,容易進行體外分離、培養和純化,且具有多嚮分化潛能.若將骨髓間充質榦細胞誘導分化為胰島細胞,可望解決胰島細胞來源和免疫排斥問題.文章對骨髓間充質榦細胞分化為胰島細胞治療糖尿病的研究進展進行綜述,併指齣瞭存在問題和今後的研究方嚮.
배경:연구발현,골수간충질간세포이식입당뇨병대서후능구강저기혈당.목적:종술골수간충질간세포재촉진이도재생방면적작용여연구현상.방법:응용계산궤검색2003년7월지2011년12월PubMed수거고상관문장,검색사위“bone marrow derive mesenchymal stem cel ,islet cel s”,병한정문장어언충류위English.동시계산궤검색2003년7월지2011년12월만방수거고상관문장,검색사위“골수간충질간세포,이도세포”,병한정문장어언충류위중문.최종납입부합표준적문헌25편.결과여결론:목전,이식이도치료당뇨병이취득량호료효,단유우이도래원궤핍화이충혹이체래원적이도인기면역배척반응이난이사음다당뇨환자수익.골수간충질간세포취재방편,용역진행체외분리、배양화순화,차구유다향분화잠능.약장골수간충질간세포유도분화위이도세포,가망해결이도세포래원화면역배척문제.문장대골수간충질간세포분화위이도세포치료당뇨병적연구진전진행종술,병지출료존재문제화금후적연구방향.
@@@@ BACKGROUND:Bone marrow mesenchymal stem cel s transplanted into diabetes mel itus rats can decrease glucose level. OBJECTIVE:To summarize the research progress in bone marrow mesenchymal stem cel s for promotion of islet regeneration. METHODS:A computer-based online retrieval of PubMed and Wanfang databases was performed to search papers published during July 2003 to December 2011 with the key words bone marrow mesenchymal stem cel s, islet cel s in English and Chinese. Twenty-five papers were included in the final analysis. RESULTS AND CONCLUSION:At present, transplantation of islets has made great advance in treatment of diabetes mel itus. Many patients with diabetes mel itus hardly benefit from islet transplantation because of limited islet origins and the immunological rejections of heterogenous or xenogenous islets. Bone marrow mesenchymal stem cel s are characterized by easy to operate, easy in vitro isolation, culture and purification, and multipotential differentiation. Islets induce-differentiated by bone marrow mesenchymal stem cel s are expected to solve islet-related problems of the limited origin and immunological rejections. This paper summarizes the research progress in bone marrow mesenchymal stem cel s for treatment of diabetes mel itus and points out the existing problems and further study direction.
