CAJ | 학술논문

背景:骨髓间充质干细胞移植修复损伤海马具有较高的研究潜力,但是目前移植后干细胞的成活率较低这一问题尚未得到有效解决.目的:综述中药干预对创伤性应激障碍大鼠海马区移植间充质干细胞的保护作用.方法:应用计算机检索2000年1月至2012年1月PubMed数据库相关文章,检索词为“mesenchymal stem cel s,transplantation,survival,post-traumatic stress disorder (PTSD),hippocampus”,并限定文章语言种类为English,同时检索2000年1月至2012年1月CNKI数据库相关文章,检索词为“间充质干细胞,移植,存活率,创伤后应激障碍,海马”,并限定文章语言种类为中文;共检索文献109篇.最终纳入符合标准的文献23篇.结果与结论:创伤后应激障碍作为一种由生物、心理、社会等多种因素作用的复杂疾病,治疗是亟待解决的问题,中医药在此领域具有独特的优势.创伤后应激障碍所造成的海马损伤可以通过骨髓间充质干细胞移植进行修复,运用调肝方药逍遥散干预,预期可有效提高移植干细胞的存活率.
배경:골수간충질간세포이식수복손상해마구유교고적연구잠력,단시목전이식후간세포적성활솔교저저일문제상미득도유효해결.목적:종술중약간예대창상성응격장애대서해마구이식간충질간세포적보호작용.방법:응용계산궤검색2000년1월지2012년1월PubMed수거고상관문장,검색사위“mesenchymal stem cel s,transplantation,survival,post-traumatic stress disorder (PTSD),hippocampus”,병한정문장어언충류위English,동시검색2000년1월지2012년1월CNKI수거고상관문장,검색사위“간충질간세포,이식,존활솔,창상후응격장애,해마”,병한정문장어언충류위중문;공검색문헌109편.최종납입부합표준적문헌23편.결과여결론:창상후응격장애작위일충유생물、심리、사회등다충인소작용적복잡질병,치료시극대해결적문제,중의약재차영역구유독특적우세.창상후응격장애소조성적해마손상가이통과골수간충질간세포이식진행수복,운용조간방약소요산간예,예기가유효제고이식간세포적존활솔.
BACKGROUND:Transplantation of bone marrow mesenchymal stem cel s shows great potential in repair of hippocampal injury. However, low survival rate of transplanted stem cel s remains unsolved. OBJECTIVE:To summarize the protective effects of traditional Chinese medicine on bone marrow mesenchymal stem cel s transplanted in the hippocampus of rats with post-traumatic stress disorder. METHODS:The databases of Pubmed, and CNKI were retrieved for papers published from January 2000 to January 2012 with key words“mesenchymal stem cel s, transplantation, survival and post-traumatic stress disorder (PTSD), hippocampus”in English and Chinese. A total of 109 papers were retrieved. Among them, 23 papers were included in the final analysis. RESULTS AND CONCLUSION:Post-traumatic stress disorder is a complex disease influenced by biological, psychological, social and other factors and remains unsolved in treatment. Traditional Chinese medicine exhibits a unique advantage in this research field. Hippocampal damage caused by post-traumatic stress disorder can be repaired by transplantation of bone marrow mesenchymal stem cel s. Bone marrow mesenchymal stem cel transplantation combined with intervention of Xiaoyaosan, a traditional Chinese medicine, is expected to increase the survival rate of transplanted stem cel s.