中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2013年
1期
161-166
,共6页
干细胞%干细胞综述%脐血%间充质干细胞%造血干细胞%支持造血%体外扩增%其他基金
榦細胞%榦細胞綜述%臍血%間充質榦細胞%造血榦細胞%支持造血%體外擴增%其他基金
간세포%간세포종술%제혈%간충질간세포%조혈간세포%지지조혈%체외확증%기타기금
stem cel s%stem cel review%umbilical cord blood%mesenchymal stem cel s%hematopoietic stem cel s%hematopoiesis%in vitro proliferation%other grants-supported paper
背景:脐血造血干细胞移植价值日益突出,造血干细胞体外扩增已成为干细胞领域的研究热点.目的:复习相关文献,对脐血间充质干细胞支持造血作用研究现状与应用前景进行综述.方法:应用计算机检索CNKI和PubMed数据库中2001至2012年关于脐血间充质干细胞造血支持作用的文章,中文检索词为“脐血间充质干细胞,造血干细胞,CD34+细胞,体外扩增”,英文检索词为“Hematopoietic stem cel expansion,CD34+cel expansion,Umbilical cord blood mesenchymal stem cel s”.最终选择35篇文章进入结果分析.结果与结论:脐血间充质干细胞支持造血作用的多种作用机制,包括分泌多种具有造血支持作用的细胞因子,表达与造血细胞相互作用的黏附分子等.因此,体外扩增造血干细胞,临床联合移植间充质干细胞和造血干细胞,提高造血重建的能力,具有广阔的研究前景.
揹景:臍血造血榦細胞移植價值日益突齣,造血榦細胞體外擴增已成為榦細胞領域的研究熱點.目的:複習相關文獻,對臍血間充質榦細胞支持造血作用研究現狀與應用前景進行綜述.方法:應用計算機檢索CNKI和PubMed數據庫中2001至2012年關于臍血間充質榦細胞造血支持作用的文章,中文檢索詞為“臍血間充質榦細胞,造血榦細胞,CD34+細胞,體外擴增”,英文檢索詞為“Hematopoietic stem cel expansion,CD34+cel expansion,Umbilical cord blood mesenchymal stem cel s”.最終選擇35篇文章進入結果分析.結果與結論:臍血間充質榦細胞支持造血作用的多種作用機製,包括分泌多種具有造血支持作用的細胞因子,錶達與造血細胞相互作用的黏附分子等.因此,體外擴增造血榦細胞,臨床聯閤移植間充質榦細胞和造血榦細胞,提高造血重建的能力,具有廣闊的研究前景.
배경:제혈조혈간세포이식개치일익돌출,조혈간세포체외확증이성위간세포영역적연구열점.목적:복습상관문헌,대제혈간충질간세포지지조혈작용연구현상여응용전경진행종술.방법:응용계산궤검색CNKI화PubMed수거고중2001지2012년관우제혈간충질간세포조혈지지작용적문장,중문검색사위“제혈간충질간세포,조혈간세포,CD34+세포,체외확증”,영문검색사위“Hematopoietic stem cel expansion,CD34+cel expansion,Umbilical cord blood mesenchymal stem cel s”.최종선택35편문장진입결과분석.결과여결론:제혈간충질간세포지지조혈작용적다충작용궤제,포괄분비다충구유조혈지지작용적세포인자,표체여조혈세포상호작용적점부분자등.인차,체외확증조혈간세포,림상연합이식간충질간세포화조혈간세포,제고조혈중건적능력,구유엄활적연구전경.
@@@@ BACKGROUND:With the development of umbilical cord blood hematopoietic stem cel transplantation, ex vivo expansion of hematopoietic stem cel s has been paid increasing attention. OBJECTIVE: To review relevant literatures and summarize the current research progress and clinical application of umbilical cord blood mesenchymal stem cel s supporting hematopoiesis. METHODS:CNKI and PubMed database were retrieved by computer for articles concerning umbilical cord blood mesenchymal stem cel s supporting hematopoiesis published from 2001 to 2012. The key words were“hematopoietic stem cel expansion, CD34+cel expansion, umbilical cord blood mesenchymal stem cel s”. A total of 35 articles were retrieved. RESULTS AND CONCLUSION:Many mechanisms had been involved in umbilical cord blood mesenchymal stem cel s supporting hematopoiesis, including the secretion of a variety of cytokines and the expression of adhesion molecules. Therefore, transplantation of umbilical cord blood mesenchymal stem cel s together with ex vivo expanded hematopoietic stem cel s can improve hematopoietic reconstruction with broad prospects.
