CAJ | 학술논문

背景:雷洛昔芬虽在临床中广泛应用于治疗骨质疏松,但对骨折愈合的影响尚未见报道.目的:观察雷洛昔芬对兔下颌骨骨折愈合的影响.方法:取新西兰大耳白兔24只,制备双侧下颌角1.5 mm×10.0 mm骨缺损模型,随机抽签法分为2组,实验组于造模后第2天开始给予7.5 mg/(kg?d)雷洛昔芬至30 d,对照组不作处理.结果与结论:X射线观察造模后1周两组骨缺损区骨痂形成不明显.3周实验组缺损区模糊,对照组缺损区仍可见;4周实验组骨痂多,髓腔再通;对照组骨痂较多,髓腔未通.造模后1,3,4周实验组骨密度和血清骨源性碱性磷酸酶较对照组明显升高(P<0.05),均于第4周时达到高峰;造模后3,4周实验组骨痂中骨形态发生蛋白2的表达强度高于对照组(P<0.01).提示雷洛昔芬能够促进成骨细胞分化,加速骨矿物沉积,同时诱导骨形态发生蛋白2表达从而加速骨折的愈合.
배경:뢰락석분수재림상중엄범응용우치료골질소송,단대골절유합적영향상미견보도.목적:관찰뢰락석분대토하합골골절유합적영향.방법:취신서란대이백토24지,제비쌍측하합각1.5 mm×10.0 mm골결손모형,수궤추첨법분위2조,실험조우조모후제2천개시급여7.5 mg/(kg?d)뢰락석분지30 d,대조조불작처리.결과여결론:X사선관찰조모후1주량조골결손구골가형성불명현.3주실험조결손구모호,대조조결손구잉가견;4주실험조골가다,수강재통;대조조골가교다,수강미통.조모후1,3,4주실험조골밀도화혈청골원성감성린산매교대조조명현승고(P<0.05),균우제4주시체도고봉;조모후3,4주실험조골가중골형태발생단백2적표체강도고우대조조(P<0.01).제시뢰락석분능구촉진성골세포분화,가속골광물침적,동시유도골형태발생단백2표체종이가속골절적유합.
BACKGROUND:Although raloxifene has been widely applied in the treatment of osteoporosis, its influence on fracture healing is unclear. OBJECTIVE:To investigate the effect of raloxifene on the healing of mandibular fractures in rabbits. METHODS:Total y 24 New Zealand white rabbits were col ected. Model of bilateral mandibular angle bone defect (1.5 mm×10.0 mm) in rabbits was established. Al rabbits were randomly divided into experimental and control groups. The rabbits in the experimental group were performed 7.5 mg/(kg?d) raloxifene at day 2 after modeling for 30 days, while those in the control group had no treatment. RESULTS AND CONCLUSION:X-ray observation showed that cal us formation was not obvious in the two groups after modeling for 1 week. Defect area of the experimental group was indistinct, but that of the control group could be found at week 3. At week 4, cal us in the experimental group was increased and medul ary cavity passed again. Cal us in the control group was more, and medul ary cavity did not pass. Compared with control group, bone mineral density and serum bone alkaline phosphatase in the experimental group was increased obviously after modeling for 1, 3 and 4 weeks (P<0.05), and they both reached the peak. The expression of bone morphogenetic protein 2 in cal us was higher than that of the control group after modeling for 3 and 4 weeks (P<0.01). These results suggest that raloxifene can promote osteoblast differentiation, accelerate bone mineral deposition, and induce bone morphogenetic protein 2 expression at the same time, and thereby accelerate the healing of bone fracture.