CAJ | 학술논문

组织构建%组织构建学术探讨%雌激素%成骨特异性转录因子%成骨细胞%雌激素%核因子κB%成骨调控%骨代谢%信号通路%省级基金組織構建%組織構建學術探討%雌激素%成骨特異性轉錄因子%成骨細胞%雌激素%覈因子κB%成骨調控%骨代謝%信號通路%省級基金
조직구건%조직구건학술탐토%자격소%성골특이성전록인자%성골세포%자격소%핵인자κB%성골조공%골대사%신호통로%성급기금
tissue construction%academic investigation in tissue construction%osteoblast-specific transcription factor%osteoblasts%estrogen%nuclear factor kappa B%regulation of osteogenesis%bone metabolism%signaling pathway%provincial grants-supported paper

背景:普遍认为雌激素和成骨特异性转录因子(runt-related transcription factor 2,Runx2)是骨骼形成和维持的重要调控因子.目的:分析总结目前有关成骨细胞中雌激素与 Runx2相互作用的研究进展,综述在成骨细胞中雌激素与Runx2相互作用的分子机制.方法:以“雌激素”、“成骨特异性转录因子”、“成骨细胞”、“Runx-2”、“Estrogen”为检索词,检索PubMed数据库、中国生物医学文献数据库、维普期刊全文数据库、万方数据库有关文章.排除重复性研究及无关研究.计算机初步检索得到62篇文献,经过进一步研读分析,保留22篇进行总结.结果与结论:研究发现,雌激素和Runx2在成骨细胞中并不是孤立的发挥作用,而是通过多种方式相互协同,共同发挥对成骨细胞的调控,作用于骨代谢过程.雌激素与Runx2之间存在的复杂作用机制,除E2/ER与Runx2直接作用外还涉及到许多信号系统,如转化生长因子β信号通路,Wnt/β-连锁蛋白信号通路,Fas/FasL信号通路和核因子κB信号通路等.
배경:보편인위자격소화성골특이성전록인자(runt-related transcription factor 2,Runx2)시골격형성화유지적중요조공인자.목적:분석총결목전유관성골세포중자격소여 Runx2상호작용적연구진전,종술재성골세포중자격소여Runx2상호작용적분자궤제.방법:이“자격소”、“성골특이성전록인자”、“성골세포”、“Runx-2”、“Estrogen”위검색사,검색PubMed수거고、중국생물의학문헌수거고、유보기간전문수거고、만방수거고유관문장.배제중복성연구급무관연구.계산궤초보검색득도62편문헌,경과진일보연독분석,보류22편진행총결.결과여결론:연구발현,자격소화Runx2재성골세포중병불시고립적발휘작용,이시통과다충방식상호협동,공동발휘대성골세포적조공,작용우골대사과정.자격소여Runx2지간존재적복잡작용궤제,제E2/ER여Runx2직접작용외환섭급도허다신호계통,여전화생장인자β신호통로,Wnt/β-련쇄단백신호통로,Fas/FasL신호통로화핵인자κB신호통로등.
@@@@ BACKGROUND:It is widely believed that estrogen and runt-related transcription factor 2 (Runx2) are important regulatory factors in the formation and maintenance of bone. OBJECTIVE:To summarize the recent research progresses and to elaborate the molecular mechanism of interaction between estrogen and Runx2 in osteoblasts. METHODS:“Estrogen”,“runt-related transcription factor 2 (Runx2)”and“osteoblast”were used as search terms in Chinese and English to retrieve PubMed, China Biology Medicine disc, VIP journal ful-text database, WanFang database. Repeatability studies and irrelevant researches were excluded. Total y 62 literatures were obtained with preliminary retrieval and 22 were reserved after further study and analysis. RESULTS AND CONCLUSION:A mass of scientific researchers have found that estrogen and Runx2 do not function independently in osteoblasts but interact with each other through multiple patterns to co-regulate osteoblasts. There exist a complex mechanism of interaction between estrogen and Runx2. Various pathways are involved besides the direct action between estrogen/estrogen receptor and Runx2, such as transforming growth factor-βpathway, Wnt/β-catenin pathway, Fas/Fas ligand pathway and nuclear factor kappa B pathway.