中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2013年
2期
363-368
,共6页
组织构建%组织构建学术探讨%角膜内皮细胞%载体%动物模型%角膜内皮层移植%组织工程%国家自然科学基金
組織構建%組織構建學術探討%角膜內皮細胞%載體%動物模型%角膜內皮層移植%組織工程%國傢自然科學基金
조직구건%조직구건학술탐토%각막내피세포%재체%동물모형%각막내피층이식%조직공정%국가자연과학기금
tissue construction%academic discussion in tissue construction%corneal endothelial cel s%carrier%animal models%corneal epithelium transplantation%tissue engineering%National Natural Science Foundation of China
背景:组织工程角膜内皮可以克服角膜内皮移植的短缺并能够改善角膜内皮细胞的质量,其应用前景十分广阔.因此,寻找一种理想的重建角膜内皮方法是组织工程角膜研究领域的重要课题和研究热点.目的:总结并讨论组织工程角膜内皮重建的研究进展.方法:应用计算机检索 PubMed 数据库(http://www.ncbi.nlm.nih.gov/PubMed)相关文章,检索时间为2000至2012年,检索词为“corneal endothelial cel ,transplantation,tissue engineering”,并限定文章语言种类为英语,然后再从中筛选出与主题相关的部分文献.结果与结论:初检得到163篇文章,按主题相关性对文献进一步筛选,最终纳入44篇文章.目前构建单层角膜内皮层的研究较多,也取得了巨大的成绩,但是仍没有一种材料或重建方式可以完全符合临床应用的组织工程的人角膜内皮.每一种材料和方法都各有优缺点,克服这些缺点以及观察在体内的长期影响是今后的发展方向.
揹景:組織工程角膜內皮可以剋服角膜內皮移植的短缺併能夠改善角膜內皮細胞的質量,其應用前景十分廣闊.因此,尋找一種理想的重建角膜內皮方法是組織工程角膜研究領域的重要課題和研究熱點.目的:總結併討論組織工程角膜內皮重建的研究進展.方法:應用計算機檢索 PubMed 數據庫(http://www.ncbi.nlm.nih.gov/PubMed)相關文章,檢索時間為2000至2012年,檢索詞為“corneal endothelial cel ,transplantation,tissue engineering”,併限定文章語言種類為英語,然後再從中篩選齣與主題相關的部分文獻.結果與結論:初檢得到163篇文章,按主題相關性對文獻進一步篩選,最終納入44篇文章.目前構建單層角膜內皮層的研究較多,也取得瞭巨大的成績,但是仍沒有一種材料或重建方式可以完全符閤臨床應用的組織工程的人角膜內皮.每一種材料和方法都各有優缺點,剋服這些缺點以及觀察在體內的長期影響是今後的髮展方嚮.
배경:조직공정각막내피가이극복각막내피이식적단결병능구개선각막내피세포적질량,기응용전경십분엄활.인차,심조일충이상적중건각막내피방법시조직공정각막연구영역적중요과제화연구열점.목적:총결병토론조직공정각막내피중건적연구진전.방법:응용계산궤검색 PubMed 수거고(http://www.ncbi.nlm.nih.gov/PubMed)상관문장,검색시간위2000지2012년,검색사위“corneal endothelial cel ,transplantation,tissue engineering”,병한정문장어언충류위영어,연후재종중사선출여주제상관적부분문헌.결과여결론:초검득도163편문장,안주제상관성대문헌진일보사선,최종납입44편문장.목전구건단층각막내피층적연구교다,야취득료거대적성적,단시잉몰유일충재료혹중건방식가이완전부합림상응용적조직공정적인각막내피.매일충재료화방법도각유우결점,극복저사결점이급관찰재체내적장기영향시금후적발전방향.
@@@@ BACKGROUND:Tissue-engineered corneal endothelium can overcome the shortages of donor corneas for transplantation and also improve the quality of corneal endothelial cel s. Finding a kind of ideal reconstructed corneal endothelium is very important in the field of tissue-engineered cornea. OBJECTIVE:To review and discuss the current research in the reconstruction of tissue-engineered corneal endothelium. METHODS:The PubMed database (http://www.ncbi.nlm.nih.gov/PubMed) was retrieved by computer to search the relevant literature published between 2000 and 2012 using the key words of“corneal endothelial cel , transplantation, tissue engineering”in English. Then, the paper was further analyzed and reviewed in line with the theme. RESULTS AND CONCLUSION:A total of 163 papers were searched. At last, 44 papers were selected according to the titles and objectives. So far, many kinds of biomaterials and methods have been used for reconstruction of tissue-engineered corneal endothelium. But many difficulties and problems must be solved in the clinical practice of tissue-engineered corneal endothelium. Every material and method for tissue-engineered corneal endothelium has its own advantages and disadvantages, so further research is to improve this disadvantage and investigate the long-term effects in vivo.
