医药前沿
醫藥前沿
의약전연
YIAYAO QIANYAN
2013年
5期
117-119
,共3页
樊雨良%刘沁%陆遥%富秀英%陶晓阳%李花
樊雨良%劉沁%陸遙%富秀英%陶曉暘%李花
번우량%류심%륙요%부수영%도효양%리화
慢性肾脏病%血浆五聚素 3(PTX3)%超敏C反应蛋白(hs-CRP)%肿瘤坏死因子(TNFa)%24 小时尿蛋白定量%血液透析
慢性腎髒病%血漿五聚素 3(PTX3)%超敏C反應蛋白(hs-CRP)%腫瘤壞死因子(TNFa)%24 小時尿蛋白定量%血液透析
만성신장병%혈장오취소 3(PTX3)%초민C반응단백(hs-CRP)%종류배사인자(TNFa)%24 소시뇨단백정량%혈액투석
chronic kidney disease%Pentraxin 3%high-sensitive C-reactive protein%Tumor necrosis factor-α%24-hour proteinuria%Hemodialysis
目的:探讨慢性肾脏病(CKD)患者血浆五聚素3(PTX3)水平与肾小球滤过率(GFR)、24小时尿蛋白定量的关系.方法:120例 CKD 患者分四组,每组30例:① CKD3期组;② CKD4期组;③ CKD5期非透析组;④ CKD5期透析组,另选健康对照组:健康正常人30人.患者均常规检测尿素氮、肌酐、24小时尿蛋白定量等,用简化 MDRD 公式计算各组 GFR,用放免法测定 PTX3、超敏 C 反应蛋白(hs-CRP)、肿瘤坏死因子(TNFa).结果:1.PTX3、hs-CRP、TNFa等炎症介质在①组、②组、③组、④组均明显高于健康对照组;(P<0.05).2.随着 GFR 的降低,PTX3水平逐渐升高:①组<②组<③④组(P<0.01).3. hs-CRP 随着 GFR 的降低,①组、②组、③④组呈逐渐上升趋势,但无统计学意义(P >0.05).4. TNFa 随着 GFR 的降低,①组、②组、③④组呈逐渐上升趋势,但①组、②组无统计学意义(P >0.05),而③④组>①组(P<0.05),③④组>②组(P<0.05),有统计学意义.5.24小时尿蛋白定量:③④组>②组(P<0.05),②组>①组(P<0.05),均有统计学意义.6.CKD5期血液透析组与血透前、血透后 PTX3参数无明显变化(P﹥0.05)无统计学意义.结论: CKD 患者体内都存在炎症状态,PTX3、hs-CRP 、TNFa 均高于健康人.与 CRP 相比,CKD 患者的肾功能、尿蛋白与 PTX3关系更为密切.PTX3与 CKD 患者的 GFR 呈直线负相关,与24小时尿蛋白定量呈直线正相关.studied .GFR was calculated with simplified MDRD formula, Plasma Pentraxin 3(PTX3),high-sensitive C-reactive protein(hs-CRP) and Tumor necrosis factor-alpha(TNFa) were determined by RIA. Results :1.Plasma PTX3、hs-CRP 、TNFa were at significantly higher levels in al four chronic kidney disease groups than those in control group(P<0.05).2.PTX3 level rose with GFR level falen: group ①<group ②<group ③④(P<0.01).3. hs-CRP levels of al four groups rose with GFR level falen, had no statistic significance.4.TNFa levels of al four groups rose with GFR level falen, group ①,② had no statistic significance(P﹥0.05), group ③,④﹥group ①(P<0.05) and group ③,④﹥group ②(P<0.05) had statistic significance.5.24-hour proteinuria: group ③,④﹥group ②(P<0.05) and group ②﹥group ①(P<0.05) had statistic significance.6. PTX3 level had no considerable change between before hemodialysis and after hemodialysis in group ⑤(P﹥0.05), had no statistic significance. Conclusion:Chronic inflammation was existed in patients with chronic kidney disease, Plasma PTX3、hs-CRP 、TNFa were at significantly higher levels in chronic kidney disease than those in control group. Comparing with CRP, Plasma PTX3 has a closer relationship to GFR and proteinuria .It positively linear correlates with GFR and negatively linear correlates with 24-hour proteinuria.
目的:探討慢性腎髒病(CKD)患者血漿五聚素3(PTX3)水平與腎小毬濾過率(GFR)、24小時尿蛋白定量的關繫.方法:120例 CKD 患者分四組,每組30例:① CKD3期組;② CKD4期組;③ CKD5期非透析組;④ CKD5期透析組,另選健康對照組:健康正常人30人.患者均常規檢測尿素氮、肌酐、24小時尿蛋白定量等,用簡化 MDRD 公式計算各組 GFR,用放免法測定 PTX3、超敏 C 反應蛋白(hs-CRP)、腫瘤壞死因子(TNFa).結果:1.PTX3、hs-CRP、TNFa等炎癥介質在①組、②組、③組、④組均明顯高于健康對照組;(P<0.05).2.隨著 GFR 的降低,PTX3水平逐漸升高:①組<②組<③④組(P<0.01).3. hs-CRP 隨著 GFR 的降低,①組、②組、③④組呈逐漸上升趨勢,但無統計學意義(P >0.05).4. TNFa 隨著 GFR 的降低,①組、②組、③④組呈逐漸上升趨勢,但①組、②組無統計學意義(P >0.05),而③④組>①組(P<0.05),③④組>②組(P<0.05),有統計學意義.5.24小時尿蛋白定量:③④組>②組(P<0.05),②組>①組(P<0.05),均有統計學意義.6.CKD5期血液透析組與血透前、血透後 PTX3參數無明顯變化(P﹥0.05)無統計學意義.結論: CKD 患者體內都存在炎癥狀態,PTX3、hs-CRP 、TNFa 均高于健康人.與 CRP 相比,CKD 患者的腎功能、尿蛋白與 PTX3關繫更為密切.PTX3與 CKD 患者的 GFR 呈直線負相關,與24小時尿蛋白定量呈直線正相關.studied .GFR was calculated with simplified MDRD formula, Plasma Pentraxin 3(PTX3),high-sensitive C-reactive protein(hs-CRP) and Tumor necrosis factor-alpha(TNFa) were determined by RIA. Results :1.Plasma PTX3、hs-CRP 、TNFa were at significantly higher levels in al four chronic kidney disease groups than those in control group(P<0.05).2.PTX3 level rose with GFR level falen: group ①<group ②<group ③④(P<0.01).3. hs-CRP levels of al four groups rose with GFR level falen, had no statistic significance.4.TNFa levels of al four groups rose with GFR level falen, group ①,② had no statistic significance(P﹥0.05), group ③,④﹥group ①(P<0.05) and group ③,④﹥group ②(P<0.05) had statistic significance.5.24-hour proteinuria: group ③,④﹥group ②(P<0.05) and group ②﹥group ①(P<0.05) had statistic significance.6. PTX3 level had no considerable change between before hemodialysis and after hemodialysis in group ⑤(P﹥0.05), had no statistic significance. Conclusion:Chronic inflammation was existed in patients with chronic kidney disease, Plasma PTX3、hs-CRP 、TNFa were at significantly higher levels in chronic kidney disease than those in control group. Comparing with CRP, Plasma PTX3 has a closer relationship to GFR and proteinuria .It positively linear correlates with GFR and negatively linear correlates with 24-hour proteinuria.
목적:탐토만성신장병(CKD)환자혈장오취소3(PTX3)수평여신소구려과솔(GFR)、24소시뇨단백정량적관계.방법:120례 CKD 환자분사조,매조30례:① CKD3기조;② CKD4기조;③ CKD5기비투석조;④ CKD5기투석조,령선건강대조조:건강정상인30인.환자균상규검측뇨소담、기항、24소시뇨단백정량등,용간화 MDRD 공식계산각조 GFR,용방면법측정 PTX3、초민 C 반응단백(hs-CRP)、종류배사인자(TNFa).결과:1.PTX3、hs-CRP、TNFa등염증개질재①조、②조、③조、④조균명현고우건강대조조;(P<0.05).2.수착 GFR 적강저,PTX3수평축점승고:①조<②조<③④조(P<0.01).3. hs-CRP 수착 GFR 적강저,①조、②조、③④조정축점상승추세,단무통계학의의(P >0.05).4. TNFa 수착 GFR 적강저,①조、②조、③④조정축점상승추세,단①조、②조무통계학의의(P >0.05),이③④조>①조(P<0.05),③④조>②조(P<0.05),유통계학의의.5.24소시뇨단백정량:③④조>②조(P<0.05),②조>①조(P<0.05),균유통계학의의.6.CKD5기혈액투석조여혈투전、혈투후 PTX3삼수무명현변화(P﹥0.05)무통계학의의.결론: CKD 환자체내도존재염증상태,PTX3、hs-CRP 、TNFa 균고우건강인.여 CRP 상비,CKD 환자적신공능、뇨단백여 PTX3관계경위밀절.PTX3여 CKD 환자적 GFR 정직선부상관,여24소시뇨단백정량정직선정상관.studied .GFR was calculated with simplified MDRD formula, Plasma Pentraxin 3(PTX3),high-sensitive C-reactive protein(hs-CRP) and Tumor necrosis factor-alpha(TNFa) were determined by RIA. Results :1.Plasma PTX3、hs-CRP 、TNFa were at significantly higher levels in al four chronic kidney disease groups than those in control group(P<0.05).2.PTX3 level rose with GFR level falen: group ①<group ②<group ③④(P<0.01).3. hs-CRP levels of al four groups rose with GFR level falen, had no statistic significance.4.TNFa levels of al four groups rose with GFR level falen, group ①,② had no statistic significance(P﹥0.05), group ③,④﹥group ①(P<0.05) and group ③,④﹥group ②(P<0.05) had statistic significance.5.24-hour proteinuria: group ③,④﹥group ②(P<0.05) and group ②﹥group ①(P<0.05) had statistic significance.6. PTX3 level had no considerable change between before hemodialysis and after hemodialysis in group ⑤(P﹥0.05), had no statistic significance. Conclusion:Chronic inflammation was existed in patients with chronic kidney disease, Plasma PTX3、hs-CRP 、TNFa were at significantly higher levels in chronic kidney disease than those in control group. Comparing with CRP, Plasma PTX3 has a closer relationship to GFR and proteinuria .It positively linear correlates with GFR and negatively linear correlates with 24-hour proteinuria.
Objective:To investigate the relations between plasma levels of Pentraxin 3 and glomerular filtration rate(GFR), 24-hour proteinuria in patients with chronic kidney disease. Methods:120 patients with chronic kidney disease divided into 4 groups,30 patients per group: ① Stage 3 chronic kidney disease;② Stage 4 chronic kidney disease;③ Stage 5 chronic kidney disease without hemodialysis;④ Stage 5 chronic kidney disease with hemodialysis;and 30 heathy in control group. Blood Urea Nitrogen, Serum Creatinine, 24-hour proteinuria were
