CAJ | 학술논문

目的评价巴曲酶治疗急性脑梗死的临床疗效.方法检索有关巴曲酶治疗急性脑梗死的随机对照研究文献.采用Jadad 评分评价纳入文献质量.采用 RevMan 4.2软件进行 Meta 分析.结果共有38项研究纳入分析,其中阴性对照29篇,降纤酶对照6篇,尿激酶对照3篇.巴曲酶在有效率、降低神经功能缺损评分、降低纤维蛋白原方面优于阴性对照组(P<0.05),在神经功能缺损评分方面与尿激酶无显著性差异(P>0.05),在有效率方面与降纤酶无显著性差异(P>0.05).结论巴曲酶可改善急性脑梗死患者神经功能缺损评分,降低纤维蛋白原水平.
목적평개파곡매치료급성뇌경사적림상료효.방법검색유관파곡매치료급성뇌경사적수궤대조연구문헌.채용Jadad 평분평개납입문헌질량.채용 RevMan 4.2연건진행 Meta 분석.결과공유38항연구납입분석,기중음성대조29편,강섬매대조6편,뇨격매대조3편.파곡매재유효솔、강저신경공능결손평분、강저섬유단백원방면우우음성대조조(P<0.05),재신경공능결손평분방면여뇨격매무현저성차이(P>0.05),재유효솔방면여강섬매무현저성차이(P>0.05).결론파곡매가개선급성뇌경사환자신경공능결손평분,강저섬유단백원수평.
@@@@Objective To assess the clinical effect of Batroxobin on acute cerebral infarction. Methods Randomized controlled trials (RCTs) about Batroxobin used for acute cerebral infarction were recalled. The quality of the document were assessed with Jadad scale, and the RevMan 4.3 software was used for Meta-analysis. Results 38 RCTs were recalled. 29 trials were negatively controlled, 6 controlled with Defibrase, and 3 controlled with Urokinase. Batroxobin is more effective than negative controls on neurological function score and fibrino-gen (P<0.05). There was no statistics difference between Batroxobin and Urokinase on the neurological function score (P>0.05), as well as incidence of improvement between Batroxobin and Defibrase (P>0.05). Conclusion Batroxobin can effectively improve the neurological function and reduce the fibrinogen for acute cerebral infarction.