中国血液流变学杂志
中國血液流變學雜誌
중국혈액류변학잡지
CHINESE JOURNAL OF HEMORHEOLOGY
2013年
1期
16-19
,共4页
刘芳%邓淑敏%李蕾%赵奕楠%何志义*
劉芳%鄧淑敏%李蕾%趙奕楠%何誌義*
류방%산숙민%리뢰%조혁남%하지의*
脑梗死%脂联素受体2基因%单核苷酸多态性
腦梗死%脂聯素受體2基因%單覈苷痠多態性
뇌경사%지련소수체2기인%단핵감산다태성
cerebral infarction%adiponectin receptor 2 gene%single-nucleotide polymorphisms
目的探讨脂联素受体2基因与缺血性脑卒中发病的相关性.方法用聚合酶链式反应-限制性片段长度多态性方法检测302例缺血性脑卒中患者和338名健康对照者的脂联素受体2基因(ADIPOR2)rs12342位点的基因型.结果(1)脑梗死组AA、GA、GG基因型频率分别为37.42%、43.04%、19.54%,A等位基因和G等位基因分布频率分别为58.94%、41.06%.对照组AA、GA、GG基因型频率分别为27.22%、46.15%、26.63%,A等位基因和G等位基因分布频率分别为50.30%、49.70%.病例组的AA基因型和A等位基因频率明显高于对照组(P=0.011和P=0.002).(2)携带AA基因型的个体发生缺血性脑卒中的危险是GG基因型的1.874倍(95%CI:1.221~2.876;P=0.004),校正各种混杂因素后发病危险度为1.802倍(95%CI:1.108~2.933),仍具有统计学差异(P=0.018).(3)rs12342位点与动脉粥样硬化性脑梗死的发病有关,与腔隙性脑梗死的发病无关.结论 ADIPOR2基因的rs12342位点的AA基因型和A等位基因可能增加缺血性脑卒中的发病风险,特别是动脉粥样硬化性脑梗死的发病风险,可能是缺血性脑卒中的危险因素.
目的探討脂聯素受體2基因與缺血性腦卒中髮病的相關性.方法用聚閤酶鏈式反應-限製性片段長度多態性方法檢測302例缺血性腦卒中患者和338名健康對照者的脂聯素受體2基因(ADIPOR2)rs12342位點的基因型.結果(1)腦梗死組AA、GA、GG基因型頻率分彆為37.42%、43.04%、19.54%,A等位基因和G等位基因分佈頻率分彆為58.94%、41.06%.對照組AA、GA、GG基因型頻率分彆為27.22%、46.15%、26.63%,A等位基因和G等位基因分佈頻率分彆為50.30%、49.70%.病例組的AA基因型和A等位基因頻率明顯高于對照組(P=0.011和P=0.002).(2)攜帶AA基因型的箇體髮生缺血性腦卒中的危險是GG基因型的1.874倍(95%CI:1.221~2.876;P=0.004),校正各種混雜因素後髮病危險度為1.802倍(95%CI:1.108~2.933),仍具有統計學差異(P=0.018).(3)rs12342位點與動脈粥樣硬化性腦梗死的髮病有關,與腔隙性腦梗死的髮病無關.結論 ADIPOR2基因的rs12342位點的AA基因型和A等位基因可能增加缺血性腦卒中的髮病風險,特彆是動脈粥樣硬化性腦梗死的髮病風險,可能是缺血性腦卒中的危險因素.
목적탐토지련소수체2기인여결혈성뇌졸중발병적상관성.방법용취합매련식반응-한제성편단장도다태성방법검측302례결혈성뇌졸중환자화338명건강대조자적지련소수체2기인(ADIPOR2)rs12342위점적기인형.결과(1)뇌경사조AA、GA、GG기인형빈솔분별위37.42%、43.04%、19.54%,A등위기인화G등위기인분포빈솔분별위58.94%、41.06%.대조조AA、GA、GG기인형빈솔분별위27.22%、46.15%、26.63%,A등위기인화G등위기인분포빈솔분별위50.30%、49.70%.병례조적AA기인형화A등위기인빈솔명현고우대조조(P=0.011화P=0.002).(2)휴대AA기인형적개체발생결혈성뇌졸중적위험시GG기인형적1.874배(95%CI:1.221~2.876;P=0.004),교정각충혼잡인소후발병위험도위1.802배(95%CI:1.108~2.933),잉구유통계학차이(P=0.018).(3)rs12342위점여동맥죽양경화성뇌경사적발병유관,여강극성뇌경사적발병무관.결론 ADIPOR2기인적rs12342위점적AA기인형화A등위기인가능증가결혈성뇌졸중적발병풍험,특별시동맥죽양경화성뇌경사적발병풍험,가능시결혈성뇌졸중적위험인소.
Objective To investigate the association between the rs12342 polymorphism in the ADIPOR2 gene and ischemic stroke.Methods A case-control study was performed among 302 patients with ischemic stroke and 338 unrelated controls.The genotypes of rs12342 were determined by the polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) method.Results (1)In ischemic stroke group,the frequencies of AA,GA,GG genotypes were 37.42%,43.04%,19.54%,and the frequencies of A allele and G allele were 58.94%,41.06%.In control group,the frequencies of AA,GA,GG genotypes were 27.22%,46.15%,26.63%,and the frequencies of A allele and G allele were 50.30%,49.70%.The frequencies of AA genotype and A allele were significantly higher in ischemic stroke group than in control group.(2)The AA genotype carriers had a significantly higher risk of ischemic stroke with OR 1.874(95%CI:1.221~2.876;P=0.004) than the GG genotype carrier.After adjustment for potential risk factors,rs12342 remained positive correlation with ischemic stroke (OR=1.802;95%CI=1.108~2.933,P=0.018).(3)The rs12342 was associated with cerebral thrombosis infarction,and not associated with lacunar infarction.Conclusions The AA genotype and A allele of the rs12342 polymorphism in the ADIPOR2 gene increase the susceptibility of ischemic stroke,especially cerebral thrombosis infarction.The ADIPOR2 gene may be the susceptibilitive gene of ischemic stroke.
