中国血液流变学杂志
中國血液流變學雜誌
중국혈액류변학잡지
CHINESE JOURNAL OF HEMORHEOLOGY
2013年
1期
78-81
,共4页
IgA肾病%血清IgA%血清C3%IgA/C3比值
IgA腎病%血清IgA%血清C3%IgA/C3比值
IgA신병%혈청IgA%혈청C3%IgA/C3비치
IgA nephropathy%serum IgA%serum C3%IgA/ C3 ratio
目的探讨血清IgA、C3水平及IgA/C3比值在原发性IgA肾病中的临床意义.方法以透射免疫比浊法测定69例经肾穿刺活检确诊为原发性IgA肾病患者和58例非IgA原发性肾小球肾炎患者血清IgA及C3水平,按Haas分级标准评估IgA肾病的病理分型,同时对结果进行分析.结果原发性IgA肾病患者与非IgA原发性肾小球肾炎患者血清IgA水平分别为[(3.01±0.91)vs(2.51±1.05)g/L,P<0.01];血清C3水平分别为[(1.00±0.22)vs(1.14±0.27)g/L,P<0.01];IgA/C3比值分别为(3.14±1.19 vs 2.26±0.93,P<0.01).Haas分型为Ⅰ、Ⅱ型患者与Ⅲ、Ⅳ、Ⅴ型患者血清IgA水平分别为[(2.87±0.82)vs(3.26±1.03)g/L,P>0.05];血清C3水平分别为[(0.98±0.20)vs(1.04±0.25)g/L,P>0.05];IgA/C3比值分别为(3.05±1.03 vs 3.31±1.45,P>0.05).结论血清IgA、C3水平及IgA/C3比值可作为鉴别原发性IgA肾病与非IgA肾病的参考指标.
目的探討血清IgA、C3水平及IgA/C3比值在原髮性IgA腎病中的臨床意義.方法以透射免疫比濁法測定69例經腎穿刺活檢確診為原髮性IgA腎病患者和58例非IgA原髮性腎小毬腎炎患者血清IgA及C3水平,按Haas分級標準評估IgA腎病的病理分型,同時對結果進行分析.結果原髮性IgA腎病患者與非IgA原髮性腎小毬腎炎患者血清IgA水平分彆為[(3.01±0.91)vs(2.51±1.05)g/L,P<0.01];血清C3水平分彆為[(1.00±0.22)vs(1.14±0.27)g/L,P<0.01];IgA/C3比值分彆為(3.14±1.19 vs 2.26±0.93,P<0.01).Haas分型為Ⅰ、Ⅱ型患者與Ⅲ、Ⅳ、Ⅴ型患者血清IgA水平分彆為[(2.87±0.82)vs(3.26±1.03)g/L,P>0.05];血清C3水平分彆為[(0.98±0.20)vs(1.04±0.25)g/L,P>0.05];IgA/C3比值分彆為(3.05±1.03 vs 3.31±1.45,P>0.05).結論血清IgA、C3水平及IgA/C3比值可作為鑒彆原髮性IgA腎病與非IgA腎病的參攷指標.
목적탐토혈청IgA、C3수평급IgA/C3비치재원발성IgA신병중적림상의의.방법이투사면역비탁법측정69례경신천자활검학진위원발성IgA신병환자화58례비IgA원발성신소구신염환자혈청IgA급C3수평,안Haas분급표준평고IgA신병적병리분형,동시대결과진행분석.결과원발성IgA신병환자여비IgA원발성신소구신염환자혈청IgA수평분별위[(3.01±0.91)vs(2.51±1.05)g/L,P<0.01];혈청C3수평분별위[(1.00±0.22)vs(1.14±0.27)g/L,P<0.01];IgA/C3비치분별위(3.14±1.19 vs 2.26±0.93,P<0.01).Haas분형위Ⅰ、Ⅱ형환자여Ⅲ、Ⅳ、Ⅴ형환자혈청IgA수평분별위[(2.87±0.82)vs(3.26±1.03)g/L,P>0.05];혈청C3수평분별위[(0.98±0.20)vs(1.04±0.25)g/L,P>0.05];IgA/C3비치분별위(3.05±1.03 vs 3.31±1.45,P>0.05).결론혈청IgA、C3수평급IgA/C3비치가작위감별원발성IgA신병여비IgA신병적삼고지표.
Objective To analyze the difference of serum IgA,C3 levels and IgA/ C3 ratio between the patients with primary IgA nephropathy(IgAN) and non-IgA nephropathy and observe the correlation of these parameters with Haas’s grading system in patients with IgA nephropathy.Methods 69 patients with primary IgA nephropathy and 58 patients with non-IgA nephropathy were diagnosed by renal biopsy,the levels of serum IgA,C3 were detected with turbidimetric method in all patients.Patho-grading was evaluated according to the standard of Haas grading.Results The levels of serum IgA in the patients with IgAN were significantly higher than those in patients with non-IgA nephropathy(3.01±0.91 vs 2.51±1.05g/L,P<0.01),and the serum C3 levels in the patients with IgAN were significantly lower than those in patients with non-IgA nephropathy(1.00±0.22 vs 1.14±0.27g/L,P<0.01),the IgA/ C3 ratio in IgAN group was also significantly higher than that in non-IgA group(3.14±1.19 vs 2.26±0.93,P<0.01).The serum IgA(2.87±0.82 vs 3.26±1.03g/L,P>0.05),C3 levels(0.98±0.20 vs 1.04±0.25g/L,P>0.05) and IgA/ C3 ratio(3.05±1.03 vs 3.31±1.45,P>0.05) of the patients with class Ⅲ,Ⅳ,Ⅴ was higher than classⅠand Ⅱ,but the differences between groups was not statistically significant.Conclusion The serum IgA,C3 levels and IgA/ C3 ratio could be used as reference parameter to identify primary IgA nephropathy from non-IgA nephropathy.
