CAJ | 학술논문

目的观察乳酸脱氢酶、α-羟丁酸脱氢酶和超敏C反应蛋白在系统性红斑狼疮(SLE)和神经精神性系统性红斑狼疮(NPSLE)患者血清中的差异,探讨上述指标是否与疾病活动程度及免疫学指标有相关性,及其是否可作为NPSLE早期诊断的标志.方法收集50例NPSLE患者及50例非神经精神受累的SLE患者的临床资料,比较两组血清中乳酸脱氢酶、α-羟丁酸脱氢酶和超敏C反应蛋白水平;NPSLE组内血清中乳酸脱氢酶和α-羟丁酸脱氢酶的水平与SLE病情活动及免疫学指标的相关性.结果 NPSLE患者血清中乳酸脱氢酶和α-羟丁酸脱氢酶水平明显高于非神经精神受累的SLE患者(P<0.05);两组血清中超敏C反应蛋白水平无统计学意义(P>0.05);血清中的乳酸脱氢酶及α-羟丁酸脱羧酶水平与SLE的活动性评价有一定关联性,但与免疫指标如C3、C4、ANA等无明显的统计学关系.结论 NPSLE患者血清中的乳酸脱氢酶和羟丁酸脱氢酶水平明显增高,且数值与病情活动程度呈正相关,其可作为早期诊治的指标,为临床提供诊断依据.
목적관찰유산탈경매、α-간정산탈경매화초민C반응단백재계통성홍반랑창(SLE)화신경정신성계통성홍반랑창(NPSLE)환자혈청중적차이,탐토상술지표시부여질병활동정도급면역학지표유상관성,급기시부가작위NPSLE조기진단적표지.방법수집50례NPSLE환자급50례비신경정신수루적SLE환자적림상자료,비교량조혈청중유산탈경매、α-간정산탈경매화초민C반응단백수평;NPSLE조내혈청중유산탈경매화α-간정산탈경매적수평여SLE병정활동급면역학지표적상관성.결과 NPSLE환자혈청중유산탈경매화α-간정산탈경매수평명현고우비신경정신수루적SLE환자(P<0.05);량조혈청중초민C반응단백수평무통계학의의(P>0.05);혈청중적유산탈경매급α-간정산탈최매수평여SLE적활동성평개유일정관련성,단여면역지표여C3、C4、ANA등무명현적통계학관계.결론 NPSLE환자혈청중적유산탈경매화간정산탈경매수평명현증고,차수치여병정활동정도정정상관,기가작위조기진치적지표,위림상제공진단의거.
Objective To observe the difference of lactate dehydrogenase,alpha-hydroxybutyric dehydrogenase and high-sensitivity CRP between neuropsychiatric systemic lupus erythematosus and systemic lupus erythematosus,to explore whether these indexes were associated with disease activity and immunological indexes,and in order to evaluate whether they were markers of early diagnosis.Methods Collecting 50 patients with NPSLE and 50 patients with SLE,and comparing lactate dehydrogenase,alpha-hydroxybutyric dehydrogenase and high-sensitive CRP level of the two groups in serum,whether there were differences.Statisticsing the correlation between lactate dehydrogenase or alpha-hydroxybutyric dehydrogenase levels and disease activity,lactate dehydrogenase or alpha-hydroxybutyric dehydrogenase levels and immunological indexes.Results The lactate dehydrogenase and alpha-hydroxybutyric dehydrogenase levels in serum of NPSLE patients were obviously higher than SLE patients(P<0.05),the high-sensitivity CRP level in serum of the two groups was not statistically significant(P>0.05).Lactate dehydrogenase and alpha-hydroxybutyric dehydrogenase levels in serum were related to disease activity,but were irrelevant to immunological indexes.Conclusion Lactate dehydrogenase and hydroxybutyric dehydrogenase levels in the serum of patients with NPSLE increased obviously,and were closely related to SLE disease activity.They could be markers of early diagnosis and provide theoretical basis for clinical practice.