中国血液流变学杂志
中國血液流變學雜誌
중국혈액류변학잡지
CHINESE JOURNAL OF HEMORHEOLOGY
2013年
1期
141-143
,共3页
李玉芬%崔黎黎%戚其学*
李玉芬%崔黎黎%慼其學*
리옥분%최려려%척기학*
格林-巴利综合征%抗髓鞘脂抗体%临床意义
格林-巴利綜閤徵%抗髓鞘脂抗體%臨床意義
격림-파리종합정%항수초지항체%림상의의
Guillain-Barré syndrome%serum anti-myelin antibody%dynamic change
目的探讨抗髓鞘脂抗体在格林-巴利综合征(Guillain-Barré syndrome,GBS)发病机制中的作用及其临床意义.方法用ELISA方法测定50例GBS患者和40名正常对照组血清中抗髓鞘脂抗体含量,并对其中28例患者进行动态观察.结果GBS患者血清中抗髓鞘脂抗体水平显著高于正常对照组(0.34±0.16 vs 0.22±0.08,P<0.01),GBS患者抗髓鞘脂抗体的阳性率为20%,动态观查发现GBS患者血清中抗髓鞘脂抗体水平的下降与临床症状的改善相一致.结论血清抗髓鞘脂抗体水平升高在GBS的发病机制中具有重要意义,其水平变化的观测对GBS的诊断、治疗及预防具有一定的临床意义.
目的探討抗髓鞘脂抗體在格林-巴利綜閤徵(Guillain-Barré syndrome,GBS)髮病機製中的作用及其臨床意義.方法用ELISA方法測定50例GBS患者和40名正常對照組血清中抗髓鞘脂抗體含量,併對其中28例患者進行動態觀察.結果GBS患者血清中抗髓鞘脂抗體水平顯著高于正常對照組(0.34±0.16 vs 0.22±0.08,P<0.01),GBS患者抗髓鞘脂抗體的暘性率為20%,動態觀查髮現GBS患者血清中抗髓鞘脂抗體水平的下降與臨床癥狀的改善相一緻.結論血清抗髓鞘脂抗體水平升高在GBS的髮病機製中具有重要意義,其水平變化的觀測對GBS的診斷、治療及預防具有一定的臨床意義.
목적탐토항수초지항체재격림-파리종합정(Guillain-Barré syndrome,GBS)발병궤제중적작용급기림상의의.방법용ELISA방법측정50례GBS환자화40명정상대조조혈청중항수초지항체함량,병대기중28례환자진행동태관찰.결과GBS환자혈청중항수초지항체수평현저고우정상대조조(0.34±0.16 vs 0.22±0.08,P<0.01),GBS환자항수초지항체적양성솔위20%,동태관사발현GBS환자혈청중항수초지항체수평적하강여림상증상적개선상일치.결론혈청항수초지항체수평승고재GBS적발병궤제중구유중요의의,기수평변화적관측대GBS적진단、치료급예방구유일정적림상의의.
Objective To investigate the roles of serum anti-myelin antibody in the pathogenesis of Guillain-Barré syndrome(GBS).Methods Serum anti-myelin antibody levels of 50 GBS patients and 40 normal controls were measured by ELISA,and dynamic changes of anti-myelin antibody levels in 28 GBS patients were also observed.Results Serum anti-myelin antibody levels in GBS patients were higher than those in normal controls(0.34±0.16 vs 0.22±0.08,P<0.01).Positive rate of serum anti-myelin antibody in GBS patients was 20%.Decline of serum anti-myelin levels was in parallel with symptom improvement in GBS patients.Conclusions Higher serum anti-myelin antibody level played an important role in the pathogenesis of GBS.Dynamic change of serum anti-myelin antibody level was important for the diagnosis,treatment and prevention of GBS.
