CAJ | 학술논문

目的探讨献血对绝经后女性铁过载和雌激素减少的缓解作用.方法随机选取2008年以来苏州市中心血站献血绝经后女性56名为试验组,并根据不同献血频次分为A组(1~3次)、B组(4~6次)、C组(>6次);同时选取苏州大学附属第二医院、苏州市立医院北区门诊体检的绝经后未献过血的女性56名为对照组.抽取空腹静脉血各2mL,采用非平衡竞争结合放射免疫双抗体法进行血清铁蛋白的测定,放免法进行血清雌二醇的检测.结果与对照组相比,试验组血清中铁蛋白水平显著降低,而雌二醇水平显著增加;而A、B、C组血清中铁蛋白水平及雌二醇水平无显著差异.结论献血对绝经后女性铁过载和雌激素减少有一定的缓解作用,但献血频次与其无显著相关性.
목적탐토헌혈대절경후녀성철과재화자격소감소적완해작용.방법수궤선취2008년이래소주시중심혈참헌혈절경후녀성56명위시험조,병근거불동헌혈빈차분위A조(1~3차)、B조(4~6차)、C조(>6차);동시선취소주대학부속제이의원、소주시립의원북구문진체검적절경후미헌과혈적녀성56명위대조조.추취공복정맥혈각2mL,채용비평형경쟁결합방사면역쌍항체법진행혈청철단백적측정,방면법진행혈청자이순적검측.결과여대조조상비,시험조혈청중철단백수평현저강저,이자이순수평현저증가;이A、B、C조혈청중철단백수평급자이순수평무현저차이.결론헌혈대절경후녀성철과재화자격소감소유일정적완해작용,단헌혈빈차여기무현저상관성.
s:Objective To investigate the mitigation effect of blood donation on iron overload and estradiol decrease of postmenopausal women.Methods Fifty-six blood donation postmenopausal women from Suzhou Blood Center since 2008 were enrolled as experimental group.According to their donation frequency,they were divided into three groups as follows:Group A(1~3 times),Group B(4~6 times) and Group C(>6 times).Fifty-six health postmenopausal women who had not donated blood from Second Affiliated Hospital of Soochow University and North District of Suzhou Municipal Hospital were selected as control group.Heparinized venous blood (2mL) was collected in each donor.Using the unbalanced competitive binding radioimmunoassay double antibody method,serum ferritin concentrations were detected.The production of estradiol was determined by radioimmunoassay.Results Compared with the control group,serum ferritin concentration of experimental group was significantly decreased,while the estradiol production was increased.However,there is not significant difference between Group A,Group B and Group C.Conclusion Blood donation may make a mitigation effect on iron overload and estradiol decrease of postmenopausal women to a certain extent.However,donation frequency does not significantly correlated with that.