CAJ | 학술논문

目的建立高效液相色谱法测定复方妥英麻黄茶碱胶囊的溶出度的方法.方法采用 Diamonsil(钻石)C18(150×4.6mm,5μm)色谱柱,以甲醇-水(50:50)为流动相,检测波长为215nm,流速=1.0ml/min,柱温室温.结果三批复方妥英麻黄茶碱胶囊及片剂的溶出度为82.6%(20041202)、83.3%(20041203)、84.5%(20041204)、74.9%.结论本方法简便,结果准确可靠,可用于本制剂质量控制的有效方法.
목적건립고효액상색보법측정복방타영마황다감효낭적용출도적방법.방법채용 Diamonsil(찬석)C18(150×4.6mm,5μm)색보주,이갑순-수(50:50)위류동상,검측파장위215nm,류속=1.0ml/min,주온실온.결과삼비복방타영마황다감효낭급편제적용출도위82.6%(20041202)、83.3%(20041203)、84.5%(20041204)、74.9%.결론본방법간편,결과준학가고,가용우본제제질량공제적유효방법.
Objective To establish an method for the dissolution of fufang tuoyin mahuang chajian capsules by HPLC. Methods A column of Diamonsil C18 (150×4.6mm, 5μm) was used the mobile phase consisted of methanol-water (50:50) and the flow rate was 1.0ml.min-1. The UV detection wavelength was 215nm and column temoerature was room-temoerature. Results The dissolution of batch in 20041202 was 82.6%;The dissolution of batch in 20041203 was 83.3%, The dissolution of batch in 20041204 was 84.5%The dissolution of the tablets was 74.9%. Conclusions The method is simple, accurate, useful in quality control for the capsules.