CAJ | 학술논문

目的:评价氟哌噻吨美利曲辛联合认知行为疗法治疗卒中后抑郁的的临床疗效及安全性.方法:将78例卒中后抑郁症患者随机分为氟哌噻吨美利曲辛联合认知行为疗法治疗组39例,设为治疗组,阿米替林治疗组39例,设为对照组,疗程8周,于治疗前及治疗1周、2周、4周、6周、8周末采用汉密顿抑郁量表(HAMD)评定临床疗效,采用副反应量表(TESS)评定不良反应.结果:治疗组总有效率为92.31%,对照组总有效率为69.23%,两者比较差异有统计学意义(P<0.01).对照组治疗2周末HAMD量表评分与入组时比较差异有统计学意义,但治疗组在治疗1周末即显示出明显疗效(P<0.01),两组同期HAMD量表评分比较,治疗组较对照组下降更显著(P<0.05或P<0.01);两组治疗后同期相比,TESS总分评定治疗组明显低于对照组,差异有统计学意义(P<0.05).结论:氟哌噻吨美利曲辛合并认知治疗对卒中后抑郁症疗效显著,安全性高,依从性好,可以缩短疗程,值得推广应用.
목적:평개불고새둔미리곡신연합인지행위요법치료졸중후억욱적적림상료효급안전성.방법:장78례졸중후억욱증환자수궤분위불고새둔미리곡신연합인지행위요법치료조39례,설위치료조,아미체림치료조39례,설위대조조,료정8주,우치료전급치료1주、2주、4주、6주、8주말채용한밀돈억욱량표(HAMD)평정림상료효,채용부반응량표(TESS)평정불량반응.결과:치료조총유효솔위92.31%,대조조총유효솔위69.23%,량자비교차이유통계학의의(P<0.01).대조조치료2주말HAMD량표평분여입조시비교차이유통계학의의,단치료조재치료1주말즉현시출명현료효(P<0.01),량조동기HAMD량표평분비교,치료조교대조조하강경현저(P<0.05혹P<0.01);량조치료후동기상비,TESS총분평정치료조명현저우대조조,차이유통계학의의(P<0.05).결론:불고새둔미리곡신합병인지치료대졸중후억욱증료효현저,안전성고,의종성호,가이축단료정,치득추엄응용.
Objective:To study the efficacy and safy of Flupentixol and Melitracen Tablets combined Cognitive therapy in the cure of Post-stroke depression.Method:78 cases of depression patients after stroke were randomly divided into Flupentixol and Melitracen combined with cognitive behavior therapy in the treatment group of 39 cases,as the treatment group,amitriptyline in the treatment group of 39 cases,as the control group,treatment for 8 weeks.The efficacy was evaluated with Hamilton depression rating scale before and after treatment.The efficacy was evaluated with TESS after treatment. Result:The scores of HAMD were significantly lower after treatment between two groups,the scores of HAMD in Fluoxetine combined Cognitive therapy group were significant than the amitriptyline group after 1 weeks treatments.The scores of HAMD and the decrease rates of HAMD in Fluoxetine combined Cognitive therapy group were sign ificant than the amitriptyline group after 1、2、4、6、8 week treatment.The scores of TESS in Fluoxetine combined Cognitive therapy group were significant lower than the single citalopram group(P<0.05).Conclution:Fluoxetine combined the Cognitive therapy can increase curative effect and shorten the period of treatment. It is an safe therapeutic in the treatment of Post-stroke depression gand demonstrated a better tolerability.