CAJ | 학술논문

目的:观察硒对桥本甲状腺炎(HT)患者甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)的影响.方法:选取TPOAb在100~600 IU/ml之间,TGAb在200 IU/ml到2000 IU/ml之间的HT患者66例,随机分为硒治疗组与对照组,硒治疗组(n=46)服硒酵母片(100μg,2次/d)和左甲状腺素钠片(维持TSH至0.27~4.2μIU/ml)治疗;对照组(n=20)服左甲状腺素钠片(维持TSH至0.27~4.2μIU/ml)治疗,比较两组治疗3个月后TPOAb及TGAb水平的变化.结果:治疗3个月后两组TGAb水平与治疗前相比,差异无统计学意义(P>0.05).治疗3个月后,两组TPOAb水平明显降低,但降低值差异无统计学意义(P<0.05).结论:硒对桥本甲状腺炎患者轻度增高的TPOAb及TGAb水平无明显影响.
목적:관찰서대교본갑상선염(HT)환자갑상선과양화물매항체(TPOAb)、갑상선구단백항체(TGAb)적영향.방법:선취TPOAb재100~600 IU/ml지간,TGAb재200 IU/ml도2000 IU/ml지간적HT환자66례,수궤분위서치료조여대조조,서치료조(n=46)복서효모편(100μg,2차/d)화좌갑상선소납편(유지TSH지0.27~4.2μIU/ml)치료;대조조(n=20)복좌갑상선소납편(유지TSH지0.27~4.2μIU/ml)치료,비교량조치료3개월후TPOAb급TGAb수평적변화.결과:치료3개월후량조TGAb수평여치료전상비,차이무통계학의의(P>0.05).치료3개월후,량조TPOAb수평명현강저,단강저치차이무통계학의의(P<0.05).결론:서대교본갑상선염환자경도증고적TPOAb급TGAb수평무명현영향.
Objective:To observe the effect of selenium on thyroid peroxidase antibody(TPOAb)and thyroglobulin antibody(TGAb)in patients with Hashimoto thyroiditis(HT).Method:66 patients with HT whose TPOAb levels were between 100 IU/ml and 600 IU/ml,TGAb levels were between 200 and 2000 IU/ml were randomized into selenium treatment group and control group.The selenium treatment group(n=46)received selenium yeast 200μg per day ,plus L-thyroxine to maintain TSH levels between 0.27-4.2μIU/ml;the control group received L-thyroxine to maintain TSH levels between 0.27-4.2μIU/ml.After 3 months compared the changes of TPOAb and TGAb levels in the two groups.Result:There were no significant changes of TGAb levels after 3 months of treatment compared with before treatment in the two groups(P>0.05).There were significant decrease of TPOAb levels after 3 months in the two groups,but the reduction had no significant difference between the two groups.Conclusion:Selenium has no significant effect on slightly increased TPOAb and TGAb levels in HT.