中国医药导刊
中國醫藥導刊
중국의약도간
CHINESE JOURNAL OF MEDICAL GUIDE
2013年
3期
471-472
,共2页
盐酸吡格列酮%2型糖尿病%胰岛β细胞功能%血管内皮功能
鹽痠吡格列酮%2型糖尿病%胰島β細胞功能%血管內皮功能
염산필격렬동%2형당뇨병%이도β세포공능%혈관내피공능
Hydrochloride pioglitazone rosiglitazone%Type 2 diabetes%Isletβ-cell function%Vascular endothelial function
目的:分析盐酸吡格列酮对2型糖尿病患者胰岛β细胞功能及血管内皮功能的影响.方法:回顾我科2011年9月至2012年9月期间68例2型糖尿病确诊患者的临床资料,在常规饮食控制、适当锻炼和药物辅助治疗基础上给予口服盐酸吡格列酮15mg/次,1次/d,对比连续治疗3月末与治疗前胰岛β细胞功能及血管内皮功能等情况.结果:治疗3月末与治疗前FBG、2hPG、HbA1c和BMI比较,P<0.01;胰岛素敏感指数明显上升,同时胰岛素抵抗指数明显下降,与治疗前比较,P<0.01;与治疗前VWF、TM、EPCR和hs-CRP水平比较,P<0.01.结论:盐酸吡格列酮能够明显改善T2DM患者的胰岛β细胞功能及血管内皮功能,在有效控制血糖、干预炎症过程和预防糖尿病并发症等方面具有非常重要的意义,值得临床继续研究和探讨.
目的:分析鹽痠吡格列酮對2型糖尿病患者胰島β細胞功能及血管內皮功能的影響.方法:迴顧我科2011年9月至2012年9月期間68例2型糖尿病確診患者的臨床資料,在常規飲食控製、適噹鍛煉和藥物輔助治療基礎上給予口服鹽痠吡格列酮15mg/次,1次/d,對比連續治療3月末與治療前胰島β細胞功能及血管內皮功能等情況.結果:治療3月末與治療前FBG、2hPG、HbA1c和BMI比較,P<0.01;胰島素敏感指數明顯上升,同時胰島素牴抗指數明顯下降,與治療前比較,P<0.01;與治療前VWF、TM、EPCR和hs-CRP水平比較,P<0.01.結論:鹽痠吡格列酮能夠明顯改善T2DM患者的胰島β細胞功能及血管內皮功能,在有效控製血糖、榦預炎癥過程和預防糖尿病併髮癥等方麵具有非常重要的意義,值得臨床繼續研究和探討.
목적:분석염산필격렬동대2형당뇨병환자이도β세포공능급혈관내피공능적영향.방법:회고아과2011년9월지2012년9월기간68례2형당뇨병학진환자적림상자료,재상규음식공제、괄당단련화약물보조치료기출상급여구복염산필격렬동15mg/차,1차/d,대비련속치료3월말여치료전이도β세포공능급혈관내피공능등정황.결과:치료3월말여치료전FBG、2hPG、HbA1c화BMI비교,P<0.01;이도소민감지수명현상승,동시이도소저항지수명현하강,여치료전비교,P<0.01;여치료전VWF、TM、EPCR화hs-CRP수평비교,P<0.01.결론:염산필격렬동능구명현개선T2DM환자적이도β세포공능급혈관내피공능,재유효공제혈당、간예염증과정화예방당뇨병병발증등방면구유비상중요적의의,치득림상계속연구화탐토.
@@@@Objective:To analyze hydrochloride pioglitazone in patients with type 2 diabetes β-cell function and vascular endothelial function. Methods: Retrospective our department from September 2011 to September 2012, 68 cases of type 2 diabetes diagnosed patients with the clinical data on the basis of conventional diet control, proper exercise and drugs auxiliary treatment given oral hydrochloride topiramate grid column ketone 15mg/times, 1/d, end of March, and the treatment of the former pancreaticβ-cell function and vascular endothelial function compared continuous therapy. Results:3 at the end of treatment and before treatment FBG 2hPG, HbA1c and BMI comparison, P<0.01;significantly increased insulin sensitivity index, insulin resistance index decreased significantly, compared with before treatment, P<0.01;pre-treatment of VWF, TM comparison of the EPCR and hs-CRP level, P<0.01. Conclusion:hydrochloric acid, topiramate grid rosiglitazone can significantly improve isletβ-cell function and vascular endothelial function in patients with T2DM, has a very important significance in the effective control of blood sugar and interfere with the inflammatory process and prevent diabetes complications and worthy of continued study and explore.
