CAJ | 학술논문

恶性脑胶质瘤发生发展同酪氨酸蛋白激酶(receptor tyrosine kinases,RTK)受体EphA2及其配体ephrinA1的表达功能与肿瘤细胞中的信号转导密切相关,EphA2和ephrinA1的表达受肿瘤细胞种类和微环境的影响,进而诱导肿瘤细胞及相关细胞信号转导,产生相应的生物学行为.EphA2、ephrinA1系统有望成为恶性脑胶质瘤药物治疗的新靶点.
악성뇌효질류발생발전동락안산단백격매(receptor tyrosine kinases,RTK)수체EphA2급기배체ephrinA1적표체공능여종류세포중적신호전도밀절상관,EphA2화ephrinA1적표체수종류세포충류화미배경적영향,진이유도종류세포급상관세포신호전도,산생상응적생물학행위.EphA2、ephrinA1계통유망성위악성뇌효질류약물치료적신파점.
The functions and roles of EphA2 receptor and ephrinA1 ligand in different cell types are correlated with the development and maintenance of gliomas. Moreover, their functions in tumorigenesis and tumor progression are complex and dependent on the type and microenvironment of tumor cells. These variables affect the expression of EphA2 and ephrinA1 proteins, the pathways through which they induce cell signaling transduction, and the corresponding consequences of that signaling on biological behaviors. The function of the EphA2 and ephrinA1 system is expected to be the new target of medicinal treatment for cerebral gliomas.