CAJ | 학술논문

目的探讨步长丹红注射液对急性脑梗死患者血清可溶性白细胞分化抗原40配体(sCD40L)及超敏 C-反应蛋白(hs-CRP)的影响及临床疗效.方法92例急性脑梗死患者分为两组,即常规治疗组和丹红治疗组,丹红治疗组在常规治疗基础上给予步长丹红注射液30ml 溶于0.9%氯化钠注射液250ml,1次/d,静脉滴注,共14d.治疗前后测定血 sCD40L 及 hs-CRP 的变化,并用中国卒中量表(CSS)及巴氏指数(BI)评定.结果两组患者 sCD40L 及 hs-CRP 均下降,丹红治疗组均明显低于常规治疗组(均 P<0.05).治疗后两组 CSS 及 BI 评分较治疗前均明显增加,丹红治疗组均高于常规治疗组(均 P<0.05).结论步长丹红注射液可降低急性脑梗死患者 sCD40L 及 hs-CRP 的水平,有益于患者神经功能的恢复.
목적탐토보장단홍주사액대급성뇌경사환자혈청가용성백세포분화항원40배체(sCD40L)급초민 C-반응단백(hs-CRP)적영향급림상료효.방법92례급성뇌경사환자분위량조,즉상규치료조화단홍치료조,단홍치료조재상규치료기출상급여보장단홍주사액30ml 용우0.9%록화납주사액250ml,1차/d,정맥적주,공14d.치료전후측정혈 sCD40L 급 hs-CRP 적변화,병용중국졸중량표(CSS)급파씨지수(BI)평정.결과량조환자 sCD40L 급 hs-CRP 균하강,단홍치료조균명현저우상규치료조(균 P<0.05).치료후량조 CSS 급 BI 평분교치료전균명현증가,단홍치료조균고우상규치료조(균 P<0.05).결론보장단홍주사액가강저급성뇌경사환자 sCD40L 급 hs-CRP 적수평,유익우환자신경공능적회복.
@@@@Objective To evaluate efficacy of Danhong injection for patients with acute stage of cerebral infarction and its effects on serum levels of soluble CD40 ligand (sCD40L) and high-sensitivity C-reactive protein(hs-CRP). Methods Ninety two patients with acute ischemic cerebral infarction were randomly assigned to receive Danhong injection (30ml/d, i.v drip, for 14d) in addition to routine treatment (Danhong group) or routine treatment only(control group).Serum sCD40L and hs-CRP were mea-sured, and Barthel index (BI) and Chinese stroke Scale (CSS) were assessed before and after treatment in both groups. Results The levels of sCD40L and hs-CRP were deceased after treatment in both groups, however, the levels in Danhong group were significantly lower than those in control group (P<0.05). The scores of CSS and BI of two groups were improved after treatment, while scores in Danhong group were better than those in control group (P<0.05). Conclusion Danhong injection can decrease serum levels of sCD40L and hs-CRP and improve the recovery of neural function for patients with acute cerebral infarction.