CAJ | 학술논문

目的探讨p53codon72(+119C>G,rs1042522)位点多态性与乳腺癌风险性的关系.方法通过聚合酶链反应-限制性酶切片断多态性方法(PCR-RFLP)检测289例健康对照组和289例乳腺癌患者的p53codon72多态性的基因型.结果基因型CC、CG、GG在乳腺癌组的分布频率分别为29.07%,47.05%、23.87%,在对照组的分布频率分别为20.42%、51.9%、27.68%,两者分布无显著差异(P=0.53).乳腺癌组中C等位基因和CC基因型的分布均显著高于健康对照组(P<0.05).结论 p53codon72多态性与乳腺癌的风险性相关.
목적탐토p53codon72(+119C>G,rs1042522)위점다태성여유선암풍험성적관계.방법통과취합매련반응-한제성매절편단다태성방법(PCR-RFLP)검측289례건강대조조화289례유선암환자적p53codon72다태성적기인형.결과기인형CC、CG、GG재유선암조적분포빈솔분별위29.07%,47.05%、23.87%,재대조조적분포빈솔분별위20.42%、51.9%、27.68%,량자분포무현저차이(P=0.53).유선암조중C등위기인화CC기인형적분포균현저고우건강대조조(P<0.05).결론 p53codon72다태성여유선암적풍험성상관.
Objective o study on the relationship of Genetic polymorphisms of p53codon72 with risk of breast cancer. Methods The genotypes of p53codon72 were analyzed by PCR-based restriction fragment length polymorphism(RFLP) method in 289 breast cancer patients and 289 healthy people controls. Results The genotype frequencies for CC, CG, GG were 29.07%, 47.05%,23.87%in breast cancer patients and 20.42%,51.9%,27.68%in healthy subjects, respectively. No significant difference in the distribution of p53codon72 genotype was found between cases and controls(P=0.53). The frequencies of the C allele and CC genotype were significantly higher in breast cancer patients than in healthy subjects (p<0.05). Conclusion p53 codon72 polymorphism is associated with susceptibility of breast cancer.