CAJ | 학술논문

干细胞%干细胞学术探讨%骨髓间充质干细胞%脂肪干细胞%胚胎干细胞%雌激素%雌激素受体%诱导成骨%细胞因子%组织工程%综述文献榦細胞%榦細胞學術探討%骨髓間充質榦細胞%脂肪榦細胞%胚胎榦細胞%雌激素%雌激素受體%誘導成骨%細胞因子%組織工程%綜述文獻
간세포%간세포학술탐토%골수간충질간세포%지방간세포%배태간세포%자격소%자격소수체%유도성골%세포인자%조직공정%종술문헌
stem cel s%stem cel academic discussion%bone marrow mesenchymal stem cel s%adipose-derived stem cel s%embryonic stem cel s%estrogen%estrogen receptor%osteoinductive%cytokine%tissue engineering%review literature

背景:雌激素与人体正常骨代谢有紧密联系,并可以为干细胞诱导成骨提供有利条件.目的:文章就雌激素在多种干细胞诱导成骨中的应用情况及其作用机制、安全性、效果、优缺点、突出特性等进行综述.方法:由第一作者应用计算机检索 PubMed 数据库,以“estrogen,bone marrow mesenchymal stem cel s,adipose derived stem cel s,embryonic stem cel s,osteogenesis”为检索词;应用计算机检索CNKI 数据库、万方数据库以“雌激素,骨髓间充质干细胞,脂肪干细胞,胚胎干细胞,诱导成骨”为检索词.结果与结论:最终纳入50篇文献进行分析.雌激素在人体中是最重要的内分泌激素,在干细胞诱导成骨的研究中是一种安全有效的诱导剂,促进干细胞增殖与成骨分化,并在不同干细胞上表现出来的作用特点不同.其主要作用机制为:直接作用于位于干细胞上的雌激素受体发挥作用,也可以诱导产生各种细胞因子间接影响细胞增殖与分化.雌激素的浓度等级、干细胞上雌激素受体基因的编码调控表达转录、构建细胞支架等尚存在一定的争议,需进一步研究.
배경:자격소여인체정상골대사유긴밀련계,병가이위간세포유도성골제공유리조건.목적:문장취자격소재다충간세포유도성골중적응용정황급기작용궤제、안전성、효과、우결점、돌출특성등진행종술.방법:유제일작자응용계산궤검색 PubMed 수거고,이“estrogen,bone marrow mesenchymal stem cel s,adipose derived stem cel s,embryonic stem cel s,osteogenesis”위검색사;응용계산궤검색CNKI 수거고、만방수거고이“자격소,골수간충질간세포,지방간세포,배태간세포,유도성골”위검색사.결과여결론:최종납입50편문헌진행분석.자격소재인체중시최중요적내분비격소,재간세포유도성골적연구중시일충안전유효적유도제,촉진간세포증식여성골분화,병재불동간세포상표현출래적작용특점불동.기주요작용궤제위:직접작용우위우간세포상적자격소수체발휘작용,야가이유도산생각충세포인자간접영향세포증식여분화.자격소적농도등급、간세포상자격소수체기인적편마조공표체전록、구건세포지가등상존재일정적쟁의,수진일보연구.
@@@@BACKGROUND: Estrogen is closely related to normal bone metabolism in human body and provides favorable conditions for osteogenic differentiation of stem cel s. OBJECTIVE: To summarize the application, mechanism of action, safety, efficacy, advantages/disadvantages, and characteristics of estrogen in inducing osteogenic differentiation of various stem cel s. METHODS: A computer-based online retrieval of PubMed, CNKI and Wanfang databases was performed for searching papers using the key words “estrogen, bone marrow mesenchymal stem cel s, adipose-derived stem cel s, embryonic stem cel s, osteogenesis” in English and Chinese. RESULTS AND CONCLUSION: Fifty papers were suitable for final analysis. Estrogen is the most important endocrine hormone. It is a safe and effective inducing agent used in the osteogenic differentiation of stem cel s, promotes the proliferation and differentiation of stem cel s and exerts different actions on stem cel s. Estrogen directly influences on the estrogen receptor of the stem cel s and also directly influences cel proliferation and differentiation by inducing the production of various cytokines. Nevertheless, there are some uncertainties, including estrogen level, estrogen-target gene expression and transcription on stem cel s, and cel -scaffold reconstruction, which should be further studied.