CAJ | 학술논문

背景:缺血缺氧性脑损伤后的神经再生、神经功能的恢复与缺血部位新生血管的形成和重塑有着密切的关系.血管内皮祖细胞参与出生后缺血组织的血管新生及修复,促使血液循环再通和氧气等营养物质的供应,为神经功能的恢复提供微环境.目的:探讨自体血管内皮祖细胞治疗缺血缺氧性脑损伤的可行性、有效性及安全性,探索改善脑损伤患者神经功能修复的新方法.方法:应用计算机检索 PubMed、ScienceDirect、Springerlink、CNKI、万方等数据库近10年的相关文献.英文关键词为“EPCs、endothelial progenitor cel 、stroke”等,中文关键词为“内皮祖细胞、干细胞移植、脑卒中”等,选择内容与血管内皮祖细胞治疗缺血缺氧性疾病相关的文献,同一领域文献则选近期发表的或发表在权威杂志上的文章,共纳入43篇参考文献.结果与结论:脑缺血后神经再生、神经功能的恢复与缺血部位新生血管的形成和重塑有着密切的关系,内皮祖细胞参与出生后缺血组织的血管发生及修复,促进血液循环及氧气等营养物质的供应,为神经功能的恢复提供微环境.自体血管内皮祖细胞治疗缺血缺氧性脑损伤是可行的、安全的、有效的,但仍需大量的生物学及动物实验为其临床应用提供客观的理论依据.
배경:결혈결양성뇌손상후적신경재생、신경공능적회복여결혈부위신생혈관적형성화중소유착밀절적관계.혈관내피조세포삼여출생후결혈조직적혈관신생급수복,촉사혈액순배재통화양기등영양물질적공응,위신경공능적회복제공미배경.목적:탐토자체혈관내피조세포치료결혈결양성뇌손상적가행성、유효성급안전성,탐색개선뇌손상환자신경공능수복적신방법.방법:응용계산궤검색 PubMed、ScienceDirect、Springerlink、CNKI、만방등수거고근10년적상관문헌.영문관건사위“EPCs、endothelial progenitor cel 、stroke”등,중문관건사위“내피조세포、간세포이식、뇌졸중”등,선택내용여혈관내피조세포치료결혈결양성질병상관적문헌,동일영역문헌칙선근기발표적혹발표재권위잡지상적문장,공납입43편삼고문헌.결과여결론:뇌결혈후신경재생、신경공능적회복여결혈부위신생혈관적형성화중소유착밀절적관계,내피조세포삼여출생후결혈조직적혈관발생급수복,촉진혈액순배급양기등영양물질적공응,위신경공능적회복제공미배경.자체혈관내피조세포치료결혈결양성뇌손상시가행적、안전적、유효적,단잉수대량적생물학급동물실험위기림상응용제공객관적이론의거.
@@@@BACKGROUND: Fol owing ischemic/hypoxic brain injury, neurogenesis and neurofunctional recovery are closely related to vascular formation and plasticity in ischemic region. Vascular endothelial progenitor cel s participate in vascular formation and repair in postnatal ischemic tissue, promote the recanalization of blood flow and the supply of nutritive substances such as oxygen, providing microenvironment for neurofunctional recovery. OBJECTIVE: To evaluate the feasibility, efficacy and safety of use of autologous vascular endothelial progenitor cel s in the treatment of ischemic/hypoxic brain injury and investigate a new method for improving the neurological function of patients with ischemic/hypoxic brain injury. METHODS: A computer-based online retrieval of PubMed, ScienceDirect, Springerlink and CNKI databases was performed for papers describing use of vascular endothelial progenitor cel s in the treatment of ischemic/hypoxic brain injury using the key words “EPCs, endothelial progenitor cel , stroke” in English and Chinese. In the same research filed, papers that published recently or in high impact factor journals were selected. A total of 43 papers were suitable for final analysis. RESULTS AND CONCLUSION: Fol owing ischemic/hypoxic brain injury, neurogenesis and neurofunctional recovery are closely related to vascular formation and plasticity in ischemic region. Vascular endothelial progenitor cel s participate in vascular formation and repair in postnatal ischemic tissue, promote the recanalization of blood flow and the supply of nutritive substances such as oxygen, providing microenvironment for neurofunctional recovery. The use of autologous vascular endothelial progenitor cel s in the treatment of ischemic/hypoxic brain injury is feasible, safe and effective. Nevertheless, a larger number of biological and animal experiments are needed for providing theoretical evidence for clinical application of autologous vascular endothelial progenitor cel s.