CAJ | 학술논문

目的:检测狼疮性肾炎患者外周血CD4+CD25high调节性T细胞的比例,探讨其临床意义.方法:采用流式细胞仪检测35例狼疮性肾炎患者及11名健康对照者的外周血CD4+CD25high调节性T细胞的比例,并分析其与肾脏病理类型和疾病活动的相关性.结果:狼疮性肾炎患者外周血CD4+CD25high调节性T细胞的比例与健康对照组相比,差异无统计学意义(P>0.05),并与疾病活动性无相关性.但III型和IV型狼疮性肾炎患者,CD4+CD25high调节性T细胞的比例较II型和V型患者明显降低(P<0.05).结论:检测外周血CD4+CD25high调节性T细胞的比例可以辅助判断狼疮性肾炎的病理类型,并可为治疗狼疮性肾炎提供理论依据.
목적:검측랑창성신염환자외주혈CD4+CD25high조절성T세포적비례,탐토기림상의의.방법:채용류식세포의검측35례랑창성신염환자급11명건강대조자적외주혈CD4+CD25high조절성T세포적비례,병분석기여신장병리류형화질병활동적상관성.결과:랑창성신염환자외주혈CD4+CD25high조절성T세포적비례여건강대조조상비,차이무통계학의의(P>0.05),병여질병활동성무상관성.단III형화IV형랑창성신염환자,CD4+CD25high조절성T세포적비례교II형화V형환자명현강저(P<0.05).결론:검측외주혈CD4+CD25high조절성T세포적비례가이보조판단랑창성신염적병리류형,병가위치료랑창성신염제공이론의거.
Objective: To investigate the frequency of CD4+CD25high regulatory T cells in the peripheral blood of lupus nephritis patients with diverse pathology. Methods: Peripheral blood mononuclear cells from 35 lupus ne?phritis patients based on the 2003 ISN/RPS classification system and 11 healthy controls were counted and stained for CD4 and CD25. The relation between CD4+CD25high regulatory T cells and renal pathology anddisease activity was analyzed. Results: No significant difference in the frequency of CD4+CD25high regulatory T cells was noted between the lupus nephritis patients and normal controls (P>0.05). Although the frequency of this cell pop?ulations was not correlated to the disease activity (P>0.05), it was significantly decreased in lupus nephritis pa?tients with Class III and IV when compared with patients with Class II and V (P<0.05). Conclusion: CD4+CD25high regulatory T cells in the peripheral blood could be a promissory biomarker for active lupus nephritis pa?tients and this may give rationale to use regulatory T cells as target cells in the treatment of lupus nephritis.