中外医学研究
中外醫學研究
중외의학연구
CHINESE AND FOREIGN MEDICAL RESEARCH
2013年
14期
43-44
,共2页
膝骨关节炎%关节滑液%程序性死亡因子%一氧化氮%凋亡
膝骨關節炎%關節滑液%程序性死亡因子%一氧化氮%凋亡
슬골관절염%관절활액%정서성사망인자%일양화담%조망
Knee osteoarthritis%Synovial fluid%Program death%Nitric oxide%Apoptosis
目的:探讨PD-1在膝骨关节炎中的作用及其与NO的相关性.方法:研究对象包括膝骨关节炎患者45例,正常人28例,应用ELISA测定PD-1在关节滑液中的表达程度和测定NO的浓度.结果:PD-1的KOA试验组与对照组比较差异有统计学意义(P<0.01),KOA患者的滑液中PD-1的水平显著高于对照组.NO的试验组与对照组比较差异有统计学意义(P<0.01),KOA患者的滑液中NO的水平显著高于对照组.试验组中PD-1与NO水平作Spearman相关分析,相关系数为r=0.915(P<0.01),两者呈正相关.结论:PD-1可能是KOA发病过程中促进关节滑液炎症、介导软骨退变的重要因子.
目的:探討PD-1在膝骨關節炎中的作用及其與NO的相關性.方法:研究對象包括膝骨關節炎患者45例,正常人28例,應用ELISA測定PD-1在關節滑液中的錶達程度和測定NO的濃度.結果:PD-1的KOA試驗組與對照組比較差異有統計學意義(P<0.01),KOA患者的滑液中PD-1的水平顯著高于對照組.NO的試驗組與對照組比較差異有統計學意義(P<0.01),KOA患者的滑液中NO的水平顯著高于對照組.試驗組中PD-1與NO水平作Spearman相關分析,相關繫數為r=0.915(P<0.01),兩者呈正相關.結論:PD-1可能是KOA髮病過程中促進關節滑液炎癥、介導軟骨退變的重要因子.
목적:탐토PD-1재슬골관절염중적작용급기여NO적상관성.방법:연구대상포괄슬골관절염환자45례,정상인28례,응용ELISA측정PD-1재관절활액중적표체정도화측정NO적농도.결과:PD-1적KOA시험조여대조조비교차이유통계학의의(P<0.01),KOA환자적활액중PD-1적수평현저고우대조조.NO적시험조여대조조비교차이유통계학의의(P<0.01),KOA환자적활액중NO적수평현저고우대조조.시험조중PD-1여NO수평작Spearman상관분석,상관계수위r=0.915(P<0.01),량자정정상관.결론:PD-1가능시KOA발병과정중촉진관절활액염증、개도연골퇴변적중요인자.
Objective:Explore the role of PD-1 in knee osteoarthritis and its correlation with NO.Methods:The study population consisted of 45 cases of patients with osteoarthritis of the knee normal 28 cases,using ELISA determination of PD-1 in the synovial fluid in the expression of the degree of concentration and determination of NO.Results:PD-1 the KOA experimental group and the control group was statistically significant(P<0.01),KOA synovial fluid of patients with significantly higher levels of PD-1. The NO experimental group and control group was statistically significant (P<0.01),significantly higher levels of NO in the synovial fluid of patients with KOA. Experimental group of PD-1 and NO levels Spearman correlation analysis,the correlation coefficient of r=0.915 (P<0.01), and a positive correlation.Conclusion:PD-1 may be an important factor to the KOA pathogenesis promote inflammation of the synovial fluid mediated cartilage degeneration.
