按摩与康复医学
按摩與康複醫學
안마여강복의학
Chinese Manipulation & Rehabilitation Medicine
2013年
1期
92-93
,共2页
阿糖腺苷%除杂%8-巯基阿糖腺苷%产率??
阿糖腺苷%除雜%8-巰基阿糖腺苷%產率??
아당선감%제잡%8-구기아당선감%산솔??
vidarabine%removingimpurity%8-sulfhydryl vidarabine%yield
阿糖腺苷杂质的处理较难,故只能在生产过程中进行.笔者通过对各步中间体的分析,利用第6步中间体(8-巯基阿糖腺苷)的水溶性对其先除去杂质,最后达到产品除杂和提高产率的目的.
阿糖腺苷雜質的處理較難,故隻能在生產過程中進行.筆者通過對各步中間體的分析,利用第6步中間體(8-巰基阿糖腺苷)的水溶性對其先除去雜質,最後達到產品除雜和提高產率的目的.
아당선감잡질적처리교난,고지능재생산과정중진행.필자통과대각보중간체적분석,이용제6보중간체(8-구기아당선감)적수용성대기선제거잡질,최후체도산품제잡화제고산솔적목적.
The dispose of the impurity in vidarabine is difficult, so it only can proceed in the productive process. The author analyzed each steps of the intermediate, made use of the water solu-bility of the intermediates (8-sulfhydryl vidarabine) in step 6 to remove impurity, and finally at-tained the goal that improving the yield.
