CAJ | 학술논문

目的:探讨人参皂苷 Rb1对青霉素所致癫痫大鼠作用.方法:将大鼠随机分为正常(A)组、模型(B)组及人参皂苷 Rb1(C)组.采用青霉素制作癫痫模型制作方法,观察 B 组及 C 组大鼠癫痫发作潜伏期及发作持续时间,并测定各组大鼠海马组织(SOD)、(MDA)含量.结果:C 组大鼠发作潜伏期较 B 组明显延长(P<0.01),发作时间显著缩短(P<0.05). C 组大鼠 SOD 活性与B 组相比显著升高(P<0.01),与 A 组比较明显降低(P<0.05). C 组 MDA 含量与 B 组比较显著降低(P<0.01),与 A 组比较差异无统计学意义(P>0.05).结论:人参皂苷 Rb1可通过抗氧化机制发挥抗癫痫作用.
목적:탐토인삼조감 Rb1대청매소소치전간대서작용.방법:장대서수궤분위정상(A)조、모형(B)조급인삼조감 Rb1(C)조.채용청매소제작전간모형제작방법,관찰 B 조급 C 조대서전간발작잠복기급발작지속시간,병측정각조대서해마조직(SOD)、(MDA)함량.결과:C 조대서발작잠복기교 B 조명현연장(P<0.01),발작시간현저축단(P<0.05). C 조대서 SOD 활성여B 조상비현저승고(P<0.01),여 A 조비교명현강저(P<0.05). C 조 MDA 함량여 B 조비교현저강저(P<0.01),여 A 조비교차이무통계학의의(P>0.05).결론:인삼조감 Rb1가통과항양화궤제발휘항전간작용.
Objective:To explore ginsenoside Rb1 to penicillin cause epilepsy rat role. Methods: The rats were randomly divided into normal (A) group, model group (B)and ginseng saponin Rb1 (C)group. Using the penicillin production epilepsy model making method, Observe group B and C group of rats epileptic seizure incubation period and the attack last time, And determinate the rat hippocampal tissue(SOD) and(MDA)content.Results:C rats, seizure incubation period was significantly longer than group B(P<0.01). Onset time was significantly shortened(P<0.05). C rats, SOD activity compared with group B significantly increased(P<0.01). And group A comparison decreased obviously (P<0.05). C group of MDA content and group B is significantly reduced (P<0.01). And group A of comparative differences no statistical significance (P>0.05). Conclusions:ginsenoside Rb1 can through the antioxidant mechanism to play antiepileptic effect.