CAJ | 학술논문

目的观察鸦胆子油乳联合FOLFIRI方案化疗与单纯FOLFIRI方案化疗对晚期结直肠癌患者的疗效以及对生活质量的影响.方法将109例患有晚期结直肠癌患者随机分为两组:治疗组,在FOLFIRI化疗方案基础上加用鸦胆子油乳治疗;对照组,单纯接受FOLFIRI方案化疗.对109例患者追踪2个月,观察并比较患者的疗效、体力状况、生活质量、不良反应等方面的差异.结果在FOLFIRI方案化疗基础上加用鸦胆子油乳治疗后,患者经中医症候评定疗效与单纯FOLFIRI方案化疗相比差异具有统计学意义(P<0.05);在改善患者体力状况、生活质量方面均优于单纯FOLFIRI方案化疗(P<0.05);在化疗所引发的白细胞、血红蛋白和血小板降低等不良反应发生率方面低于单纯FOLFIRI方案化疗组(P<0.05).结论鸦胆子油乳联合FOLFIRI方案化疗治疗晚期结直肠癌不仅可以起到化疗增效的作用,而且能够明显提高患者生活质量和体力状况,降低化疗引发的不良反应,这一联合治疗方案可以在临床治疗中推广.
목적관찰아담자유유연합FOLFIRI방안화료여단순FOLFIRI방안화료대만기결직장암환자적료효이급대생활질량적영향.방법장109례환유만기결직장암환자수궤분위량조:치료조,재FOLFIRI화료방안기출상가용아담자유유치료;대조조,단순접수FOLFIRI방안화료.대109례환자추종2개월,관찰병비교환자적료효、체력상황、생활질량、불량반응등방면적차이.결과재FOLFIRI방안화료기출상가용아담자유유치료후,환자경중의증후평정료효여단순FOLFIRI방안화료상비차이구유통계학의의(P<0.05);재개선환자체력상황、생활질량방면균우우단순FOLFIRI방안화료(P<0.05);재화료소인발적백세포、혈홍단백화혈소판강저등불량반응발생솔방면저우단순FOLFIRI방안화료조(P<0.05).결론아담자유유연합FOLFIRI방안화료치료만기결직장암불부가이기도화료증효적작용,이차능구명현제고환자생활질량화체력상황,강저화료인발적불량반응,저일연합치료방안가이재림상치료중추엄.
Objective To observe the differences between FOLFIRI chemotherapy and Fructus Brucea Oil Emulsion combination with chemotherapy treatment for the advanced colorectal cancer (CRC) patients’ therapeutic effect and the quality of life. Methods 109 cases advanced CRC patients were randomly divided into chemotherapy group and Fructus Brucea Oil Emulsion combination with chemotherapy group. Chemotherapy group was treated with FOLFIRI scheme. The other group was treated with Fructus Brucea Oil Emulsion and FOLFIRI scheme. All patients were observed for two months and analyzed the differences in the therapeutic effect, body quality score, quality of life score and toxic effect. Results Fructus Brucea Oil Emulsion combination with FOLFIRI scheme is superior to FOLFIRI scheme in the therapeutic effect and improvement of body quality score, quality of life score and the decrease of toxic effect (P<0.05). Conclusion Fructus Brucea Oil Emulsion combination with FOLFIRI scheme could increase the therapeutic effect, improve the life quality and body quality of the patients and decrease the incidence of toxic effect induced by chemotherapy.